Development of a Triplet-Triplet Absorption Ruler: DNA- and Chromatin-Mediated Drug Molecule Release from a Nanosurface

被引：4

作者：

Das Chakraborty, Sudeshna ^{[1
]}

Sau, Abhishek ^{[1
]}

Kuznetsov, Denis V. ^{[3
]}

Banerjee, Amrita ^{[2
]}

Bardhan, Munmun ^{[1
]}

Bhattacharya, Maireyee ^{[1
]}

Dasgupta, Dipak ^{[2
]}

Basu, Samita ^{[1
]}

Senapati, Dulal ^{[1
]}

机构：

[1] Saha Inst Nucl Phys, Div Chem Sci, 1-AF Bidhannagar, Kolkata 700064, India

[2] Saha Inst Nucl Phys, Biophys & Struct Genom Div, 1-AF Bidhannagar, Kolkata 700064, India

[3] Natl Univ Sci & Technol MISiS, Dept Funct Nanosyst & High Temp Mat, Leninsky Prospect 4, Moscow 119049, Russia

来源：

JOURNAL OF PHYSICAL CHEMISTRY B | 2016年 / 120卷 / 27期

关键词：

Triplet-triplet absorption or laser flash photolysis; SERS; NSET; drug; Sgr; ctDNA; chromatin; ENHANCED RAMAN-SCATTERING; SANGUINARINE; ALKALOIDS; ELECTRON; BINDING; CHELERYTHRINE; FLUORESCENCE; SPECTROSCOPY; BERBERINE; CELLS;

D O I：

10.1021/acs.jpcb.6b05278

中图分类号：

O64 [物理化学（理论化学）、化学物理学];

学科分类号：

070304 ; 081704 ;

摘要：

Triplet-triplet (T-T) absorption spectroscopy has been used successfully as a molecular ruler to understand the actual release process of sanguinarine as a drug molecule from a gold nanoparticle surface in the presence of cell components, that is, DNA and chromatin. The obtained results have been verified by fluorescence and surface-enhanced Raman spectroscopy (SERS), and a plausible explanation has been put forward to describe the underestimation and overestimation of the percentage (%) of the release of drug molecules measured by fluorescence- and SERS-based techniques, respectively, over the highlighted T-T absorption spectroscopy. Because of the intrinsic nature of absorption, the reported T-T absorption spectroscopic assay overpowers fluorescence- and SERS-based assays, which are limited by the long-range interaction and nonlinear dependence of the concentration of analytes, respectively.

引用

页码：6872 / 6881

页数：10

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