Acute Megakaryoblastic Leukemia with Myelodysplasia-related Changes Associated with ATM Gene Deletion

被引：2

作者：

Ureshino, Hiroshi ^{[1
,2
]}

Tanabe, Momoka ^{[2
]}

Kurogi, Kazuya ^{[2
]}

Miyahara, Masaharu ^{[2
]}

Kimura, Shinya ^{[1
]}

机构：

[1] Saga Univ, Fac Med, Dept Internal Med, Div Hematol Resp Med & Oncol, Saga, Japan

[2] Karatsu Red Cross Hosp, Dept Internal Med, Saga, Japan

来源：

INTERNAL MEDICINE | 2016年 / 55卷 / 12期

关键词：

acute megakaryoblastic leukemia; myelodysplasia; azacitidine; ataxia telangiectasia mutated (ATM) gene; ACUTE MYELOID-LEUKEMIA; ACUTE MEGAKARYOCYTIC LEUKEMIA; CHRONIC LYMPHOCYTIC-LEUKEMIA; CONVENTIONAL CARE REGIMENS; PROGNOSTIC SCORING SYSTEM; NEWLY-DIAGNOSED AML; OLDER PATIENTS; INTENSIVE CHEMOTHERAPY; ATAXIA-TELANGIECTASIA; AZACITIDINE;

D O I：

10.2169/internalmedicine.55.5890

中图分类号：

R5 [内科学];

学科分类号：

1002 ; 100201 ;

摘要：

Ataxia telangiectasia mutated (ATM) is a tumor suppressor gene, and its somatic inactivation plays a role in the pathogenesis of lymphoid malignancies. However, the role of ATM in patients with myeloid malignancies is still unknown. We herein report a case of acute megakaryoblastic leukemia (AMKL) with ATM gene deletion. An 84-year-old Japanese woman presenting with a pale face and pancytopenia was admitted to our institution and diagnosed to have AMKL with ATM gene deletion. She was treated with intravenous azacitidine. The azacitidine treatment was effective for approximately 1 year. Somatic inactivation of the ATM gene may therefore be involved in the pathogenesis of AMKL.

引用

页码：1625 / 1629

页数：5

共 28 条

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