Fingolimod-related cryptococcal meningoencephalitis and immune reconstitution inflammatory syndrome in a patient with multiple sclerosis

被引：6
|
作者：
Cuascut, Fernando X. [1 ]
Alkabie, Samir [1 ]
Hutton, George J. [1 ]
机构：
[1] Baylor Coll Med, Maxine Mesinger Multiple Sclerosis Comprehens Car, Dept Neurol, Houston, TX 77030 USA
来源：
MULTIPLE SCLEROSIS AND RELATED DISORDERS | 2021年 / 53卷
关键词：
Multiple sclerosis; Fingolimod; Cryptococcal meningoencephalitis; Immune reconstitution inflammatory syndrome; INFECTIONS;
D O I：
10.1016/j.msard.2021.103072
中图分类号：
R74 [神经病学与精神病学];
学科分类号：
摘要：
Fingolimod is an oral medication for multiple sclerosis that sequesters certain subsets of lymphocytes in lymph nodes, reducing egress into blood and their subsequent CNS migration. The initial multi-site randomized Phase III controlled trials found rates of infection similar to those in control groups. However, post-marketing surveillance has revealed an association with several opportunistic infections, including cryptococcosis. We report a case of fingolimod-related cryptococcal meningoencephalitis and IRIS after drug discontinuation and suggest a surveillance and risk mitigation strategy.
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页数：3
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