Fingolimod-related cryptococcal meningoencephalitis and immune reconstitution inflammatory syndrome in a patient with multiple sclerosis

被引：8

作者：

Cuascut, Fernando X. ^{[1
]}

Alkabie, Samir ^{[1
]}

Hutton, George J. ^{[1
]}

机构：

[1] Baylor Coll Med, Maxine Mesinger Multiple Sclerosis Comprehens Car, Dept Neurol, Houston, TX 77030 USA

来源：

MULTIPLE SCLEROSIS AND RELATED DISORDERS | 2021年 / 53卷

关键词：

Multiple sclerosis; Fingolimod; Cryptococcal meningoencephalitis; Immune reconstitution inflammatory syndrome; INFECTIONS;

D O I：

10.1016/j.msard.2021.103072

中图分类号：

R74 [神经病学与精神病学];

学科分类号：

摘要：

Fingolimod is an oral medication for multiple sclerosis that sequesters certain subsets of lymphocytes in lymph nodes, reducing egress into blood and their subsequent CNS migration. The initial multi-site randomized Phase III controlled trials found rates of infection similar to those in control groups. However, post-marketing surveillance has revealed an association with several opportunistic infections, including cryptococcosis. We report a case of fingolimod-related cryptococcal meningoencephalitis and IRIS after drug discontinuation and suggest a surveillance and risk mitigation strategy.

引用

页数：3

共 13 条

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