Fingolimod-related cryptococcal meningoencephalitis and immune reconstitution inflammatory syndrome in a patient with multiple sclerosis

被引：8

作者：

Cuascut, Fernando X. ^{[1
]}

Alkabie, Samir ^{[1
]}

Hutton, George J. ^{[1
]}

机构：

[1] Baylor Coll Med, Maxine Mesinger Multiple Sclerosis Comprehens Car, Dept Neurol, Houston, TX 77030 USA

来源：

MULTIPLE SCLEROSIS AND RELATED DISORDERS | 2021年 / 53卷

关键词：

Multiple sclerosis; Fingolimod; Cryptococcal meningoencephalitis; Immune reconstitution inflammatory syndrome; INFECTIONS;

D O I：

10.1016/j.msard.2021.103072

中图分类号：

R74 [神经病学与精神病学];

学科分类号：

摘要：

Fingolimod is an oral medication for multiple sclerosis that sequesters certain subsets of lymphocytes in lymph nodes, reducing egress into blood and their subsequent CNS migration. The initial multi-site randomized Phase III controlled trials found rates of infection similar to those in control groups. However, post-marketing surveillance has revealed an association with several opportunistic infections, including cryptococcosis. We report a case of fingolimod-related cryptococcal meningoencephalitis and IRIS after drug discontinuation and suggest a surveillance and risk mitigation strategy.

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页数：3

相关论文

共 13 条

[1]

Alroughani R, 2014, BMJ Case Rep, V2014, DOI 10.1136/bcr-2014-206314

[2] Invasive Fungal Infections after Natural Disasters [J].

Benedict, Kaitlin ;

Park, Benjamin J. .

EMERGING INFECTIOUS DISEASES, 2014, 20 (03) :349-355

[3] Cryptococcal meningitis in a multiple sclerosis patient treated with Fingolimod: a case report and review of imaging findings [J].

Chong, Insun ;

Wang, Kevin Yuqi ;

Lincoln, Christie M. .

CLINICAL IMAGING, 2019, 54 :53-56

[4] Hurricane-Associated Mold Exposures Among Patients at Risk for Invasive Mold Infections After Hurricane Harvey - Houston, Texas, 2017 [J].

Chow, Nancy A. ;

Toda, Mitsuru ;

Pennington, Audrey F. ;

Anassi, Enock ;

Atmar, Robert L. ;

Cox-Ganser, Jean M. ;

Da Silva, Juliana ;

Garcia, Bobbiejean ;

Kontoyiannis, Dimitrios P. ;

Ostrosky-Zeichner, Luis ;

Leining, Lauren M. ;

McCarty, Jennifer ;

Al Mohajer, Mayar ;

Murthy, Bhavini Patel ;

Park, Ju-Hyeong ;

Schulte, Joann ;

Shuford, Jennifer A. ;

Skrobarcek, Kimberly A. ;

Solomon, Samantha ;

Strysko, Jonathan ;

Chiller, Tom M. ;

Jackson, Brendan R. ;

Chew, Ginger L. ;

Beer, Karlyn D. .

MMWR-MORBIDITY AND MORTALITY WEEKLY REPORT, 2019, 68 (21) :469-473

[5]

Engelthaler D.M., 2019, TSUNAMIS BLACK SWANS

[6] Management of Cryptococcus gattii meningoencephalitis [J].

Franco-Paredes, Carlos ;

Womack, Tanea ;

Bohlmeyer, Teri ;

Sellers, Brenda ;

Hays, Allison ;

Patel, Kalpesh ;

Lizarazo, Jairo ;

Lockhart, Shawn R. ;

Siddiqui, Wajid ;

Marr, Kieren A. .

LANCET INFECTIOUS DISEASES, 2015, 15 (03) :348-355

[7] Rebound Syndrome in Patients With Multiple Sclerosis After Cessation of Fingolimod Treatment [J].

Hatcher, Stacy Ellen ;

Waubant, Emmanuelle ;

Nourbakhsh, Bardia ;

Crabtree-Hartman, Elizabeth ;

Graves, Jennifer S. .

JAMA NEUROLOGY, 2016, 73 (07) :790-794

[8] Fingolimod in the treatment of relapsing-remitting multiple sclerosis: long-term experience and an update on the clinical evidence [J].

Khatri, Bhupendra O. .

THERAPEUTIC ADVANCES IN NEUROLOGICAL DISORDERS, 2016, 9 (02) :130-147

[9] Cryptococcus neoformans var grubii meningoencephalitis in a patient on fingolimod for relapsing-remitting multiple sclerosis: Case report and review of published cases [J].

Ma, S. B. ;

Griffin, D. W. J. ;

Boyd, S. C. ;

Chang, C. C. ;

Wong, J. S. J. ;

Guy, S. D. .

MULTIPLE SCLEROSIS AND RELATED DISORDERS, 2020, 39

[10]

Mino M., 2020, J CLIN RHEUMATOL PRA