Acupuncture Treatment Reduced the Risk of Coronary Heart Disease in Patients with Depression: A Propensity-Score Matched Cohort Study

被引：6

作者：

Huang, Chia-Yu ^{[1
,2
]}

Huang, Ming-Cheng ^{[2
,3
]}

Sun, Mao-Feng ^{[2
,3
]}

Lin, Cheng-Li ^{[4
,5
]}

Wu, Mei-Yao ^{[3
,6
]}

Lin, Wu-Chou ^{[1
,2
,7
]}

Yen, Hung-Rong ^{[1
,2
,3
,8
,9
]}

机构：

[1] Buddhist Tzu Chi Med Fdn, Taichung Tzu Chi Hosp, Dept Family Med, Taichung 427, Taiwan

[2] China Med Univ, Coll Chinese Med, Sch Chinese Med, Grad Inst Chinese Med, Taichung 404, Taiwan

[3] China Med Univ Hosp, Dept Chinese Med, Taichung 404, Taiwan

[4] China Med Univ Hosp, Management Off Hlth Data, Taichung 404, Taiwan

[5] China Med Univ, Coll Med, Taichung 404, Taiwan

[6] China Med Univ, Coll Chinese Med, Sch Postbaccalaureate Chinese Med, Taichung 404, Taiwan

[7] China Med Univ Hosp, Dept Obstet & Gynecol, Taichung 404, Taiwan

[8] China Med Univ Hosp, Res Ctr Tradit Chinese Med, Dept Med Res, Taichung 404, Taiwan

[9] China Med Univ, Chinese Med Res Ctr, Taichung 404, Taiwan

来源：

NEUROPSYCHIATRIC DISEASE AND TREATMENT | 2021年 / 17卷

关键词：

acupuncture; depression; coronary heart disease; National Health Insurance Research Database; real-world evidence; RANDOMIZED CONTROLLED-TRIAL; CARDIOVASCULAR-DISEASE; ARTERY-DISEASE; SEROTONIN; ELECTROACUPUNCTURE; SYSTEM; ANTIDEPRESSANTS; EPIDEMIOLOGY; METAANALYSIS; ASSOCIATION;

D O I：

10.2147/NDT.S315572

中图分类号：

R74 [神经病学与精神病学];

学科分类号：

摘要：

Background: Major depressive disorder is a significant public health concern, which often leads to loss of productivity, functional decline, and various complications. The aim of this study was to investigate the effectiveness of acupuncture in the risk reduction of coronary heart disease (CHD) in patients with depression. Methods: We enrolled patients diagnosed with depression between January 1, 1997, and December 31, 2010, through the Taiwanese National Health Insurance Research Database (NHIRD). Propensity score was used to match equal numbers (n=14,647) of acupuncture cohort and no-acupuncture cohort based on characteristics including sex, age, baseline comorbidity and medication. Patients were followed up until December 31, 2013, or withdrawn from the NHIRD. The Cox regression model was used to compare the hazard ratios (HRs) of CHD in the two cohorts. Results: The basic characteristics of the two groups were similar. A lower cumulative incidence of CHD was noted in the acupuncture cohort (Log rank test, p < 0.001). Over time, 1626 patients in the acupuncture cohort (21.05 per 1000 person-years) and 2412 patients in the no-acupuncture cohort (39.84 per 1000 person-years) developed CHD (adjusted HR=0.50, 95% CI 0.47-0.53). The decreased CHD incidence was independent of age, sex, comorbidities, and medications used. The cumulative incidence of CHD was significantly lower in the acupuncture cohort than in the no-acupuncture cohort (Log rank test, p<0.001). Conclusion: The results provided a real-world evidence that acupuncture may have beneficial effect on CHD risk reduction in patients with depression.

引用

页码：2315 / 2325

页数：11

共 52 条

[1] Stronger symptoms of depression predict high coronary heart disease mortality in older men and women [J].