Association of 49245A>G (rs868) Polymorphism in the 3′UTR of Donor TGFBR1 Gene with Course of Hepatitis C following Orthotopic Liver Transplantation

被引：2
作者：
Ziarkiewicz-Wroblewska, Bogna [1 ]
Sajjad, Emir [2 ]
Ciszek, Michal [3 ]
Hutnik, Lukasz [4 ]
Lukasik, Dominika [1 ]
Fedorowicz, Mikolaj [4 ]
Wroblewski, Tadeusz [5 ]
Patkowski, Waldemar [5 ]
Paczek, Leszek [3 ]
Ploski, Rafal [6 ]
Wlodarski, Pawel [4 ]
Malejczyk, Jacek [4 ]
机构：
[1] Med Univ Warsaw, Dept Pathol, Ctr Biostruct Res, Warsaw, Poland
[2] Med Univ Warsaw, Ctr Biostruct Res, Histol & Embryol, Warsaw, Poland
[3] Med Univ Warsaw, Inst Transplantol, Dept Immunol Transplantol & Internal Med, Warsaw, Poland
[4] Med Univ Warsaw, Dept Histol & Embryol, Ctr Biostruct Res, Warsaw, Poland
[5] Med Univ Warsaw, Dept Gen Transplant & Liver Surg, Warsaw, Poland
[6] Med Univ Warsaw, Dept Med Genet, Ctr Biostruct Res, Warsaw, Poland
来源：
ANNALS OF TRANSPLANTATION | 2014年 / 19卷
关键词：
Hepatitis C; Liver Transplantation; MicroRNAs; Polymorphism; Single Nucleotide; GROWTH-FACTOR-BETA; ALLELE-SPECIFIC EXPRESSION; VIRUS-INFECTION; TRANSFORMING GROWTH-FACTOR-BETA-1; HISTOLOGICAL ACTIVITY; HCV INFECTION; T-CELLS; CIRRHOSIS; RECURRENT; CANCER;
D O I：
10.12659/AOT.891119
中图分类号：
R61 [外科手术学];
学科分类号：
摘要：
Background: Terminal hepatitis C is one of the leading indications for orthotopic liver transplantation (OLT). However, hepatitis C virus (HCV) reinfection occurs in almost all recipients and usually leads to progressive fibrosis and graft failure. Transforming growth factor-beta (TGF-beta) plays a part in transplanted liver cirrhosis, but nothing is known about the possible role of genetic diversity of TGF-b receptor system. Therefore, the aim of our study was to investigate whether genetic variation in 3' untranslated region (3'UTR) of TGF-b receptor type I (TGFBR1) gene is associated with recurrence and severity of hepatitis C and liver fibrosis following OLT in HCV-infected patients. Material/Methods: The study group included 95 chronic hepatitis C patients following OLT. The recipients and donors were genotyped for 49245A>G (rs868) and 51976G>A (rs334349) single nucleotide polymorphisms (SNP). Results: Donor rs868 AA genotype was strongly associated with worse clinical course of recurrent hepatitis C. The rs868 AA group displayed more severe symptoms of hepatitis C during the follow-up and the fibrosis score in this group was significantly higher 3 years after OLT. Conclusions: Clinical course of hepatitis C after OLT may depend on donor rs868 SNP located in TGFBR1 3'UTR.
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收藏
页码：643 / 651
页数：9
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