The diagnosis of dementia due to Alzheimer's disease: Recommendations from the National Institute on Aging-Alzheimer's Association workgroups on diagnostic guidelines for Alzheimer's disease

被引：11341

作者：

McKhann, Guy M. ^{[1
,2
]}

Knopman, David S. ^{[3
]}

Chertkow, Howard ^{[4
,5
]}

Hyman, Bradley T. ^{[6
]}

Jack, Clifford R., Jr. ^{[7
]}

Kawas, Claudia H. ^{[8
,9
,10
]}

Klunk, William E. ^{[11
]}

Koroshetz, Walter J. ^{[12
]}

Manly, Jennifer J. ^{[13
,14
,15
]}

Mayeux, Richard ^{[13
,14
,15
]}

Mohs, Richard C. ^{[16
]}

Morris, John C. ^{[17
]}

Rossor, Martin N. ^{[18
]}

Scheltens, Philip ^{[19
,20
]}

Carrillo, Maria C. ^{[21
]}

Thies, Bill ^{[21
]}

Weintraub, Sandra ^{[22
,23
]}

Phelps, Creighton H. ^{[24
]}

机构：

[1] Johns Hopkins Univ, Sch Med, Dept Neurol, Baltimore, MD 21205 USA

[2] Johns Hopkins Univ, Zanvyl Krieger Mind Brain Inst, Baltimore, MD 21205 USA

[3] Mayo Clin, Dept Neurol, Rochester, MN USA

[4] McGill Univ, Dept Neurol, Sch Med, Montreal, PQ H3A 2T5, Canada

[5] Lady Davis Inst, Bloomfield Ctr Res Aging, Montreal, PQ, Canada

[6] Harvard Univ, Sch Med, Dept Neurol, Massachusetts Gen Hosp, Boston, MA 02115 USA

[7] Mayo Clin, Dept Radiol, Rochester, MN USA

[8] Univ Calif Irvine, Dept Neurol, Irvine, CA 92717 USA

[9] Univ Calif Irvine, Dept Neurobiol & Behav, Irvine, CA USA

[10] Univ Calif Irvine, Alzheimer Dis Res Ctr, Irvine, CA USA

[11] Univ Pittsburgh, Sch Med, Dept Psychiat, Pittsburgh, PA USA

[12] NINDS, Bethesda, MD 20892 USA

[13] Columbia Univ, Med Ctr, Taub Inst Res Alzheimers Dis & Aging Brain, New York, NY USA

[14] Columbia Univ, Gertrude H Sergievsky Ctr, Med Ctr, New York, NY 10027 USA

[15] Columbia Univ, Dept Neurol, Med Ctr, New York, NY USA

[16] Eli Lilly & Co, Indianapolis, IN 46285 USA

[17] Washington Univ, Sch Med, Dept Neurol, St Louis, MO 63110 USA

[18] UCL, Dementia Res Ctr, Dept Neurodegenerat, UCL Inst Neurol, London, England

[19] Vrije Univ Amsterdam, Dept Neurol, Med Ctr, Amsterdam, Netherlands

[20] Vrije Univ Amsterdam, Alzheimer Ctr, Med Ctr, Amsterdam, Netherlands

[21] Alzheimers Assoc, Chicago, IL USA

[22] NW Feinberg Sch Med, Dept Psychiat, Chicago, IL USA

[23] NW Feinberg Sch Med, Dept Neurol, Chicago, IL USA

[24] NIA, Alzheimers Dis Ctr Program, Bethesda, MD 20892 USA

来源：

ALZHEIMERS & DEMENTIA | 2011年 / 7卷 / 03期

关键词：

Alzheimer's disease; Dementia; Diagnosis; Magnetic resonance brain imaging; Positron emission tomography; Cerebrospinal fluid; FRONTOTEMPORAL DEMENTIA; WORK GROUP; CRITERIA; BIOMARKERS; CONSENSUS; ATROPHY;

D O I：

10.1016/j.jalz.2011.03.005

中图分类号：

R74 [神经病学与精神病学];

学科分类号：

摘要：

The National Institute on Aging and the Alzheimer's Association charged a workgroup with the task of revising the 1984 criteria for Alzheimer's disease (AD) dementia. The workgroup sought to ensure that the revised criteria would be flexible enough to be used by both general healthcare providers without access to neuropsychological testing, advanced imaging, and cerebrospinal fluid measures, and specialized investigators involved in research or in clinical trial studies who would have these tools available. We present criteria for all-cause dementia and for AD dementia. We retained the general framework of probable AD dementia from the 1984 criteria. On the basis of the past 27 years of experience, we made several changes in the clinical criteria for the diagnosis. We also retained the term possible AD dementia, but redefined it in a manner more focused than before. Biomarker evidence was also integrated into the diagnostic formulations for probable and possible AD dementia for use in research settings. The core clinical criteria for AD dementia will continue to be the cornerstone of the diagnosis in clinical practice, but biomarker evidence is expected to enhance the pathophysiological specificity of the diagnosis of AD dementia. Much work lies ahead for validating the biomarker diagnosis of AD dementia. (C) 2011 The Alzheimer's Association. All rights reserved.

引用

页码：263 / 269

页数：7

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