Relationship Between Gene Polymorphism of Methylenetetrahydrofolate Reductase C677T and Left Ventricular Hypertrophy in Chinese Patients with Chronic Kidney Disease

被引：1

作者：

Wu, Xie ^{[1
,2
]}

Lin, Jing ^{[1
,2
,3
,4
]}

Xue, Ning ^{[1
,3
,4
]}

Teng, Jie ^{[1
,2
,3
,4
]}

Wang, Yaqiong ^{[1
,3
,4
]}

Li, Yang ^{[1
,2
]}

Xu, Xunhui ^{[1
,2
]}

Shen, Ziyan ^{[1
,3
,4
]}

Ding, Xiaoqiang ^{[1
,2
,3
,4
]}

Fang, Yi ^{[1
,2
,3
,4
]}

机构：

[1] Fudan Univ, Zhongshan Hosp, Dept Nephrol, Shanghai, Peoples R China

[2] Fudan Univ, Zhongshan Hosp, Shanghai Key Lab Kidney & Blood Purificat, Shanghai, Peoples R China

[3] Fudan Univ, Zhongshan Hosp, Shanghai Med Ctr Kidney Dis, Shanghai, Peoples R China

[4] Fudan Univ, Zhongshan Hosp, Shanghai Inst Kidney & Dialysis, Shanghai, Peoples R China

来源：

LABORATORY MEDICINE | 2021年 / 52卷 / 06期

关键词：

methylenetetrahydrofolate reductase; gene polymorphism; homocysteine; left ventricular hypertrophy; chronic kidney disease; CARDIOVASCULAR-DISEASE; MTHFR VARIANT; HOMOCYSTEINE; HYPERHOMOCYSTEINEMIA; ASSOCIATION; MUTATION; RISK; HYPERTENSION; MANAGEMENT; LEADS;

D O I：

10.1093/labmed/lmab004

中图分类号：

R446 [实验室诊断]; R-33 [实验医学、医学实验];

学科分类号：

1001 ;

摘要：

Objective: This study aimed to investigate the relationship between the gene polymorphism of methylenetetrahydrofolate reductase (MTHFR) C677T and left ventricular hypertrophy (LVH) in patients with chronic kidney disease (CKD). Methods: A total of 763 Chinese patients with CKD undergoing genetic testing were included in the study. The association between the gene polymorphism of MTHFR C677T and echocardiographic parameters was analyzed through univariate and multivariate analyses. Results: We found a remarkably positive association between MTHFR C677T gene polymorphism and LVH indexes, including interventricular septal thickness (F = 3.8; P = .022), left ventricular posterior wad thickness (F = 3.0; P = .052), left ventricular mass (F = 3.9; P = .022), and left ventricular mass index (F = 2.6; P = .075). After adjusting for the potential confounders linking the polymorphism,we found that the positive association between the polymorphism and LVH indexes still existed in patients with CKD in some multiple linear regression models (P <.05). Conclusion: MTHFR C677T gene polymorphism may be a genetic susceptibility marker for the development of LVH in patients with CKD.

引用

页码：519 / 527

页数：9

共 49 条

[1] ACE I/D and MTHFR C677T polymorphisms are significantly associated with type 2 diabetes in Arab ethnicity: A meta-analysis [J].

Al-Rubeaan, Khalid ;

Siddiqui, Khalid ;

Saeb, Amr T. M. ;

Nazir, Nyla ;

Al-Naqeb, Dhekra ;

Al-Qasim, Sara .

GENE, 2013, 520 (02) :166-177

[2]

Ala OA, 2017, DIABETES METAB SYND, V11, pS803, DOI 10.1016/j.dsx.2017.06.002

[3] Association of polymorphism in the thermolabile 5, 10-methylene tetrahydrofolate reductase gene and hyperhomocysteinemia with coronary artery disease [J].

Alam, Mohammad A. ;

Husain, Syed A. ;

Narang, Rajiv ;

Chauhan, Shayam S. ;

Kabra, Madhulika ;

Vasisht, Suman .

MOLECULAR AND CELLULAR BIOCHEMISTRY, 2008, 310 (1-2) :111-117

[4] Evidence for the existence of the PAF acetylhydrolase mutation (Va1279Phe) in non-Japanese populations: A preliminary study in Turkey, Azerbaijan, and Kyrgyzstan [J].

Balta, G ;

Gurgey, A ;

Kudayarov, DK ;

Tunc, B ;

Altay, C .

THROMBOSIS RESEARCH, 2001, 101 (04) :231-234

[5] Ventricular hypertrophy and left atrial dilatation persist and are associated with reduced survival after valve replacement for aortic stenosis [J].

Beach, Jocelyn M. ;

Mihaljevic, Tomislav ;

Rajeswaran, Jeevanantham ;

Marwick, Thomas ;

Edwards, Samuel T. ;

Nowicki, Edward R. ;

Thomas, James ;

Svensson, Lars G. ;

Griffin, Brian ;

Gillinov, A. Marc ;

Blackstone, Eugene H. .

JOURNAL OF THORACIC AND CARDIOVASCULAR SURGERY, 2014, 147 (01) :362-+

[6] LEFT ATRIAL SIZE AND THE RISK OF STROKE AND DEATH - THE FRAMINGHAM HEART-STUDY [J].

BENJAMIN, EJ ;

DAGOSTINO, RB ;

BELANGER, AJ ;

WOLF, PA ;

LEVY, D .

CIRCULATION, 1995, 92 (04) :835-841

[7] Common methylenetetrahydrofolate reductase gene mutation leads to hyperhomocysteinemia but not to vascular disease -: The result of a meta-analysis [J].

Brattström, L ;

Wilcken, DEL ;

Öhrvik, J ;

Brudin, L .

CIRCULATION, 1998, 98 (23) :2520-2526

[8]

Cao ZW, 2015, INT J CLIN EXP PATHO, V8, P12829

[9] Association between polymorphism of MTHFR c.677C>T and risk of cardiovascular disease in Turkish population: a meta-analysis for 2.780 cases and 3.022 controls [J].

Cetintas, Vildan Bozok ;

Gunduz, Cumhur .

MOLECULAR BIOLOGY REPORTS, 2014, 41 (01) :397-409

[10] The relationship between methylenetetrahydrofolate reductase C677T polymorphism and diabetic retinopathy: A meta-analysis in multiethnic groups [J].

Chen, Da ;

Wang, Jihong ;

Dan, Zengrenqing ;

Shen, Xi ;

Ci, Danyangji .

OPHTHALMIC GENETICS, 2018, 39 (02) :200-207

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