Photothermal and mechanical stimulation of cells via dualfunctional nanohybrids

被引：5

作者：

Chechetka, Svetlana A. ^{[1
]}

Doi, Motomichi ^{[2
,3
]}

Pichon, Benoit P. ^{[4
]}

Begin-Colin, Sylvie ^{[4
]}

Miyako, Eijiro ^{[1
]}

机构：

[1] Natl Inst Adv Ind Sci & Technol, Nanomat Res Inst, Cent 5,1-1-1 Higashi, Tsukuba, Ibaraki 3058565, Japan

[2] AIST, Biomed Res Inst, Cent 6,1-1-1 Higashi, Tsukuba, Ibaraki 3058566, Japan

[3] AIST, DAILAB, Cent 6,1-1-1 Higashi, Tsukuba, Ibaraki 3058566, Japan

[4] Inst Phys & Chim Mat Strasbourg, CNRS UdS ECPM, UMR 7504, 23 Rue Loess,BP 43, F-67034 Strasbourg 2, France

来源：

NANOTECHNOLOGY | 2016年 / 27卷 / 47期

基金：

日本学术振兴会;

关键词：

carbon nanotube; cell stimulation; magnetic nanoparticle; TRPV2; IRON-OXIDE NANOPARTICLES; CARBON NANOTUBES; CAPSAICIN-RECEPTOR; REMOTE-CONTROL; MAGNETITE NANOPARTICLES; GENE-EXPRESSION; LIQUID POLYOLS; ION-CHANNEL; SIZE; ACTIVATION;

D O I：

10.1088/0957-4484/27/47/475102

中图分类号：

TB3 [工程材料学];

学科分类号：

0805 ; 080502 ;

摘要：

Stimulating cells by light is an attractive technology to investigate cellular function and deliver innovative cell-based therapy. However, current techniques generally use poorly biopermeable light, which prevents broad applicability. Here, we show that a new type of composite nanomaterial, synthesized from multi-walled carbon nanotubes, magnetic iron nanoparticles, and polyglycerol, enables photothermal and mechanical control of Ca2+ influx into cells overexpressing transient receptor potential vanilloid type-2. The nanohybrid is simply operated by application of highly biotransparent near-infrared light and a magnetic field. The technology may revolutionize remote control of cellular function.

引用

页数：10

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