Generation, repair and replication of guanine oxidation products

被引：82

作者：

Kino, Katsuhito ^{[1
]}

Hirao-Suzuki, Masayo ^{[2
]}

Morikawa, Masayuki ^{[3
]}

Sakaga, Akane ^{[1
]}

Miyazawa, Hiroshi ^{[1
]}

机构：

[1] Tokushima Bunri Univ, Kagawa Sch Pharmaceut Sci, Mol Biol Lab, 1314-1 Shido, Sanuki, Kagawa 7692193, Japan

[2] Hiroshima Int Univ, Fac Pharmaceut Sci, Lab Xenobiot Metab & Environm Toxicol, 5-1-1 Hiro Koshingai, Kure, Hiroshima 7370112, Japan

[3] Tokushima Bunri Univ, Kagawa Sch Pharmaceut Sci, Lab Med Chem, 1314-1 Shido, Sanuki, Kagawa 7692193, Japan

来源：

GENES AND ENVIRONMENT | 2017年 / 39卷

基金：

日本学术振兴会;

关键词：

Oxidation; Guanine; G:C-C:G transversions; 2,2,4-triamino-5(2H)-oxazolone (oz); Base pair; DNA polymerase; Repair; Contiguous oz; Highest occupied molecular orbital (HOMO); Quadruplex DNA; ONE-ELECTRON OXIDATION; DNA-POLYMERASES ALPHA; DOUBLE-STRANDED DNA; CRYSTAL-STRUCTURE; IN-VITRO; DAMAGED GUANINE; POTENT SOURCES; LESION BYPASS; OPPOSITE; 2,2,4-TRIAMINO-5(2H)-OXAZOLONE;

D O I：

10.1186/s41021-017-0081-0

中图分类号：

Q3 [遗传学];

学科分类号：

071007 ; 090102 ;

摘要：

Guanine is the most readily oxidized of the four DNA bases, and guanine oxidation products cause G:C-T: A and G: C-C: G transversions through DNA replication. 8-Oxo-7,8-dihydroguanine (8-oxoG) causes G: C-T: A transversions but not G: C-C: G transversions, and is more readily oxidized than guanine. This review covers four major findings. (i) 2,2,4-Triamino-5(2H)oxazolone (Oz) is produced from guanine and 8-oxoG under various oxidative conditions. Guanine is incorporated opposite Oz by DNA polymerases, except REV1. (ii) Several enzymes exhibit incision activity towards Oz. (iii) Since the redox potential of GG is lower than that of G, contiguous GG sequences are more readily oxidized by a one-electron oxidant than a single guanine, and OzOz is produced from GG in double-stranded DNA. Unlike most DNA polymerases, DNA polymerase zeta efficiently extends the primer up to full-length across OzOz. (iv) In quadruplex DNA, 3'-guanine is mainly damaged by one-electron oxidation in quadruplex DNA, and this damage depends on the highest occupied molecular orbital (HOMO). The oxidation products in quadruplex DNA are different from those in single-stranded or double-stranded DNA.

引用

页数：8

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Genes and Environment, 37 (1)

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