[Cu(maloNHC)]-catalyzed synthesis of 2-aryl pyrazolo[5,1-a]isoquinolines by annulation of N′-(2-((trimethylsilyflethynyl)benzylidene)hydrazides with terminal aromatic alkynes

被引：11
作者：
Liu, Huixin [1 ]
Lu, Le [1 ]
Hua, Ruimao [1 ]
机构：
[1] Tsinghua Univ, Dept Chem, Key Lab Organ Optoelect & Mol Engn, Minist Educ, Beijing 100084, Peoples R China
来源：
TETRAHEDRON | 2017年 / 73卷 / 45期
基金：
中国国家自然科学基金;
关键词：
Annulation; Alkynes; Pyrazolo[5,1-a]isoquinolines; N-heterocyclic carbene; C-H ACTIVATION; ONE-POT APPROACH; PYRAZOLE DERIVATIVES; CASCADE REACTION; BIOLOGICAL EVALUATION; 3+2 CYCLOADDITION; CLICK CHEMISTRY; EFFICIENT; ISOQUINOLINES; CATALYSIS;
D O I：
10.1016/j.tet.2017.09.037
中图分类号：
O62 [有机化学];
学科分类号：
070303 ; 081704 ;
摘要：
A [Cu(maioNHC)]-catalyzed synthesis of 2-aryl pyrazolo[5,1-a]isoquinolines via annulation of N'-(2((trimethylsilyl)ethynyl)benzylidene)hydrazides with terminal aromatic alkynes was developed. (C) 2017 Elsevier Ltd. All rights reserved.
引用
收藏
页码：6428 / 6435
页数：8
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