Novel macrolactins as antibiotic lactones from a marine bacterium

被引：80
|
作者：
Nagao, T [1 ]
Adachi, K [1 ]
Sakai, M [1 ]
Nishijima, M [1 ]
Sano, H [1 ]
机构：
[1] Marine Biotechnol Inst Co Ltd, Shimizu Labs, Shimizu, Shizuoka 4240037, Japan
来源：
JOURNAL OF ANTIBIOTICS | 2001年 / 54卷 / 04期
关键词：
D O I：
10.7164/antibiotics.54.333
中图分类号：
Q81 [生物工程学（生物技术）]; Q93 [微生物学];
学科分类号：
071005 ; 0836 ; 090102 ; 100705 ;
摘要：
Seven new macrolactins (named G-M) and known macrolactins A and F were isolated from a culture broth of Bacillus sp. PP19-H3. The strain had been isolated from the macroalga, Schizymenia dubyi. Macrolactin A, which was 24-membered lactone, had previously been reported to show antibacterial, cytotoxic and antiviral activities. The new macrolactins include 22-membered ring or dicyclic lactone in addition to geometric isomers of known macrolactins A and E The antibacterial activities of all the macrolactins examined in this study were relatively weak.
引用
收藏
页码：333 / 339
页数：7
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