Novel macrolactins as antibiotic lactones from a marine bacterium

被引：80

作者：

Nagao, T ^{[1
]}

Adachi, K ^{[1
]}

Sakai, M ^{[1
]}

Nishijima, M ^{[1
]}

Sano, H ^{[1
]}

机构：

[1] Marine Biotechnol Inst Co Ltd, Shimizu Labs, Shimizu, Shizuoka 4240037, Japan

来源：

JOURNAL OF ANTIBIOTICS | 2001年 / 54卷 / 04期

关键词：

D O I：

10.7164/antibiotics.54.333

中图分类号：

Q81 [生物工程学（生物技术）]; Q93 [微生物学];

学科分类号：

071005 ; 0836 ; 090102 ; 100705 ;

摘要：

Seven new macrolactins (named G-M) and known macrolactins A and F were isolated from a culture broth of Bacillus sp. PP19-H3. The strain had been isolated from the macroalga, Schizymenia dubyi. Macrolactin A, which was 24-membered lactone, had previously been reported to show antibacterial, cytotoxic and antiviral activities. The new macrolactins include 22-membered ring or dicyclic lactone in addition to geometric isomers of known macrolactins A and E The antibacterial activities of all the macrolactins examined in this study were relatively weak.

引用

页码：333 / 339

页数：7

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