Emerging roles for lncRNA-NEAT1 in colorectal cancer

被引：38

作者：

Azizidoost, Shirin ^{[1
]}

Ghaedrahmati, Farhoodeh ^{[2
]}

Anbiyaee, Omid ^{[3
]}

Ali, Riyadh Ahmad ^{[4
]}

Cheraghzadeh, Maryam ^{[5
]}

Farzaneh, Maryam ^{[6
]}

机构：

[1] Ahvaz Jundishapur Univ Med Sci, Atherosclerosis Res Ctr, Ahvaz, Iran

[2] Isfahan Univ Med Sci, Sch Med, Dept Immunol, Esfahan, Iran

[3] Shiraz Univ Med Sci, Nemazi Hosp, Cardiovasc Res Ctr, Sch Med, Shiraz, Iran

[4] Lebanese French Univ, Coll Hlth Sci, Dept Med Lab Sci, Kurdistan, Kurdistan Regio, Iraq

[5] Ahvaz Jundishapur Univ Med Sci, Sch Med, Dept Biochem, Ahvaz, Iran

[6] Ahvaz Jundishapur Univ Med Sci, Fertil Infertil & Perinatol Res Ctr, Ahvaz, Iran

来源：

CANCER CELL INTERNATIONAL | 2022年 / 22卷 / 01期

关键词：

Colorectal cancer; lncRNAs; NEAT1; Progression; LONG NONCODING RNA; 5-FU SENSITIVITY; COLON-CANCER; NEAT1; PROGRESSION; CELLS; INCREASES; APOPTOSIS; AUTOPHAGY; INVASION;

D O I：

10.1186/s12935-022-02627-6

中图分类号：

R73 [肿瘤学];

学科分类号：

100214 ;

摘要：

Colorectal cancer (CRC) is the third cause of cancer death in the world that arises from the glandular and epithelial cells of the large intestine, during a series of genetic or epigenetic alternations. Recently, long non-coding RNAs (lncRNAs) has opened a separate window of research in molecular and translational medicine. Emerging evidence has supported that lncRNAs can regulate cell cycle of CRC cells. LncRNA NEAT1 has been verified to participate in colon cancer development and progression. NEAT1 as a competing endogenous RNA could suppress the expression of miRNAs, and then regulate molecules downstream of these miRNAs. In this review, we summarized emerging roles of NEAT1 in CRC cells.

引用

页数：10

共 117 条

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