An oxidized lipid-peroxisome proliferator-activated receptor γ-chemokine pathway in the regulation of macrophage-vascular smooth muscle cell adhesion

被引：24
作者：
Barlic, Jana
Murphy, Philip M.
机构：
[1] Imperial Coll London, Fac Med, Natl Heart & Lung Inst, Leukocyte Biol Sect, London SW7 2AZ, England
[2] NIH, NIAID, Immunol Mol Lab, Mol Signaling Sect, Bethesda, MD 20892 USA
来源：
TRENDS IN CARDIOVASCULAR MEDICINE | 2007年 / 17卷 / 08期
关键词：
D O I：
10.1016/j.tcm.2007.09.004
中图分类号：
R5 [内科学];
学科分类号：
1002 ; 100201 ;
摘要：
Recent genetic studies have implicated pro-inflammatory chemokines and chemokine receptors in atherogenesis. Studies at the molecular and cellular levels have suggested specific atherogenic mechanisms for two chemokine-chemokine receptor pairs, CCL2-CCR2 and CX3CL1-CX3CR1, involving differential receptor regulation by the transcription factor peroxisome proliferator-activated receptor gamma. This pathway is triggered by oxidized proatherogenic lipids, such as oxidized low-density lipoprotein and linoleic acid derivatives, which promote differentiation of CCR2(hi)CX3CRI(lo) human monocytes to CCR2(lo)CX3CR1(hi) macrophages that adhere to coronary artery smooth muscle cells in a CX3CR1- and peroxisome proliferator-activated receptor gamma-dependent manner. Switching CX3CR1 on and CCR2 off in vivo may result in cessation of CCR2-dependent migration and activation of CX3CR1-dependent retention that together may promote foam cell accumulation in the vessel wall.
引用
收藏
页码：269 / 274
页数：6
相关论文
共 69 条
[1]   Monocyte chemoattractant protein-1 accelerates atherosclerosis in apolipoprotein E-deficient mice [J].
Aiello, RJ ;
Bourassa, PAK ;
Lindsey, S ;
Weng, WF ;
Natoli, E ;
Rollins, BJ ;
Milos, PM .
ARTERIOSCLEROSIS THROMBOSIS AND VASCULAR BIOLOGY, 1999, 19 (06) :1518-1525
[2]   Conditional disruption of the peroxisome proliferator-activated receptor γ gene in mice results in lowered expression of ABCA1, ABCG1, and apoE in macrophages and reduced cholesterol efflux [J].
Akiyama, TE ;
Sakai, S ;
Lambert, G ;
Nicol, CJ ;
Matsusue, K ;
Pimprale, S ;
Lee, YH ;
Ricote, M ;
Glass, CK ;
Brewer, HB ;
Gonzalez, FJ .
MOLECULAR AND CELLULAR BIOLOGY, 2002, 22 (08) :2607-2619
[3]   Conditional knockout of macrophage PPARγ increases atherosclerosis in C57BL/6 and low-density lipoprotein receptor-deficient mice [J].
Babaev, VR ;
Yancey, PG ;
Ryzhov, SV ;
Kon, V ;
Breyer, MD ;
Magnuson, MA ;
Fazio, S ;
Linton, MF .
ARTERIOSCLEROSIS THROMBOSIS AND VASCULAR BIOLOGY, 2005, 25 (08) :1647-1653
[4]   PPARγ is required for placental, cardiac, and adipose tissue development [J].
Barak, Y ;
Nelson, MC ;
Ong, ES ;
Jones, YZ ;
Ruiz-Lozano, P ;
Chien, KR ;
Koder, A ;
Evans, RM .
MOLECULAR CELL, 1999, 4 (04) :585-595
[5]   Oxidized lipid-driven chemokine receptor switch, CCR2 to CX3CR1, mediates adhesion of human macrophages to coronary artery smooth muscle cells through a peroxisome proliferator-activated receptor γ-dependent pathway [J].
Barlic, Jana ;
Zhang, Yuan ;
Foley, John F. ;
Murphy, Philip M. .
CIRCULATION, 2006, 114 (08) :807-819
[6]   Dominant negative mutations in human PPARγ associated with severe insulin resistance, diabetes mellitus and hypertension [J].
Barroso, I ;
Gurnell, M ;
Crowley, VEF ;
Agostini, M ;
Schwabe, JW ;
Soos, MA ;
Maslen, GL ;
Williams, TDM ;
Lewis, H ;
Schafer, AJ ;
Chatterjee, VKK ;
O'Rahilly, S .
NATURE, 1999, 402 (6764) :880-883
[7]   A new class of membrane-bound chemokine with a CX(3)C motif [J].
Bazan, JF ;
Bacon, KB ;
Hardiman, G ;
Wang, W ;
Soo, K ;
Rossi, D ;
Greaves, DR ;
Zlotnik, A ;
Schall, TJ .
NATURE, 1997, 385 (6617) :640-644
[8]   Decreased lesion formation in CCR2-/- mice reveals a role for chemokines in the initiation of atherosclerosis [J].
Boring, L ;
Gosling, J ;
Cleary, M ;
Charo, IF .
NATURE, 1998, 394 (6696) :894-897
[9]   Peroxisome proliferator-activated receptor-γ activation with pioglitazone improves endothelium-dependent dilation in nondiabetic patients with major cardiovascular risk factors [J].
Campia, U ;
Matuskey, LA ;
Panza, JA .
CIRCULATION, 2006, 113 (06) :867-875
[10]   Mechanisms of disease - The many roles of chemokines and chemokine receptors in inflammation [J].
Charo, IF ;
Ransohoff, RM .
NEW ENGLAND JOURNAL OF MEDICINE, 2006, 354 (06) :610-621
1234567