The role of filaggrin in atopic dermatitis and allergic disease

被引：214

作者：

Drislane, Catherine ^{[1
]}

Irvine, Alan D. ^{[1
,2
,3
]}

机构：

[1] Trinity Coll Dublin, Med Clin, Dublin, Ireland

[2] Our Ladys Childrens Hosp Crumlin, Dept Paediat Dermatol, Dublin D12, Ireland

[3] Natl Childrens Res Ctr, Crumlin, Ireland

来源：

ANNALS OF ALLERGY ASTHMA & IMMUNOLOGY | 2020年 / 124卷 / 01期

关键词：

OF-FUNCTION MUTATIONS; PROTEASE BLEOMYCIN HYDROLASE; STRATUM-CORNEUM HYDRATION; SKIN BARRIER FUNCTION; POLYETHYLENE-GLYCOLS; ICHTHYOSIS VULGARIS; HUMAN PROFILAGGRIN; CHILDHOOD ECZEMA; NULL MUTATIONS; RARE MUTATIONS;

D O I：

10.1016/j.anai.2019.10.008

中图分类号：

R392 [医学免疫学];

学科分类号：

100102 ;

摘要：

Objective: To provide an overview of filaggrin biology and the role of filaggrin variants in atopic dermatitis (AD) and allergic disease. Data Sources: We performed a PubMed literature review consisting mainly of studies relating to filaggrin in the last 5 years. Study Selections: We selected articles that were found in PubMed using the search terms filaggrin, atopic dermatitis, skin barrier, and atopy. Results: Filaggrin plays an important role in the development of AD and allergic disease. Novel methods in measuring filaggrin expression and identifying filaggrin mutations aid in stratifying this patient cohort. We review new insights into understanding the role of filaggrin in AD and allergic disease. Conclusion: Filaggrin remains a very important player in the pathogenesis of atopic dermatitis and allergic disease. This review looks at recent studies that aid our understanding of this crucial epidermal protein. (C) 2019 Published by Elsevier Inc. on behalf of American College of Allergy, Asthma & Immunology.

引用

页码：36 / 43

页数：8

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