Opportunities and challenges of three-dimensional printing technology in pharmaceutical formulation development

被引：55
作者：
Cui, Mengsuo [1 ]
Pan, Hao [2 ]
Su, Yupei [1 ]
Fang, Dongyang [1 ]
Qiao, Sen [1 ]
Ding, Pingtian [1 ]
Pan, Weisan [1 ]
机构：
[1] Shenyang Pharmaceut Univ, Sch Pharm, Dept Pharmaceut, Shenyang 110016, Peoples R China
[2] Liaoning Univ, Sch Pharm, 66 Chongshan Middle Rd, Shenyang 110036, Peoples R China
来源：
ACTA PHARMACEUTICA SINICA B | 2021年 / 11卷 / 08期
关键词：
Three-dimensional printing technology; Drug delivery system; Pharmaceutical; Personalized medicine; Additive manufacturing; On-demand manufacturing; Advantages; Limitations and challenges; DEPOSITION MODELING FDM; DRUG-DELIVERY DEVICES; ORAL DOSAGE FORMS; CONTROLLED-RELEASE; INNOVATIVE APPROACH; MELT EXTRUSION; 3D; TABLETS; FABRICATION; STEREOLITHOGRAPHY;
D O I：
10.1016/j.apsb.2021.03.015
中图分类号：
R9 [药学];
学科分类号：
1007 ;
摘要：
Three-dimensional printing is a technology that prints the products layer-by-layer, in which materials are deposited according to the digital model designed by computer aided design (CAD) software. This technology has competitive advantages regarding product design complexity, product personalization, and on-demand manufacturing. The emergence of 3D technology provides innovative strategies and new ways to develop novel drug delivery systems. This review summarizes the application of 3D printing technologies in the pharmaceutical field, with an emphasis on the advantages of 3D printing technologies for achieving rapid drug delivery, personalized drug delivery, compound drug delivery and customized drug delivery. In addition, this article illustrates the limitations and challenges of 3D printing technologies in the field of pharmaceutical formulation development. (C) 2021 Chinese Pharmaceutical Association and Institute of Materia Medica, Chinese Academy of Medical Sciences. Production and hosting by Elsevier B.V.
引用
收藏
页码：2488 / 2504
页数：17
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