Cell-Penetrating Peptide-Functionalized Quantum Dots for Intracellular Delivery

被引：52
作者：
Liu, Betty R. [2 ,3 ]
Huang, Yue-Wern [1 ]
Chiang, Huey-Jenn [3 ]
Lee, Han-Jung [2 ]
机构：
[1] Missouri Univ Sci & Technol, Dept Biol Sci, Rolla, MO 65409 USA
[2] Natl Dong Hwa Univ, Dept Nat Resources & Environm Studies, Hualien 97401, Taiwan
[3] Natl Dong Hwa Univ, Inst Biotechnol, Hualien 97401, Taiwan
来源：
JOURNAL OF NANOSCIENCE AND NANOTECHNOLOGY | 2010年 / 10卷 / 12期
关键词：
Arginine-Rich; Cell-Penetrating Peptide; Cellular Internalization; Protein Transduction Domain; Quantum Dot; ARGININE-RICH PEPTIDES; NONCOVALENT PROTEIN TRANSDUCTION; HUMAN IMMUNODEFICIENCY VIRUS; LIVING CELLS; IN-VIVO; PLANT-CELLS; PLASMA-MEMBRANE; FUSOGENIC PEPTIDE; TAT PROTEIN; INTERNALIZATION;
D O I：
10.1166/jnn.2010.3012
中图分类号：
O6 [化学];
学科分类号：
0703 ;
摘要：
Quantum dots (QDs) are luminescent semiconductor nanocrystals that are widely used as fluorescent probes in biomedical applications, including cellular imaging and tumor tracking. Cell-penetrating peptides (CPPs), also called protein transduction domains (PTDs), are short basic peptides that permeate cell membranes and are able to deliver a variety of macromolecule cargoes, such as DNAs, RNAs, proteins, and nanomaterials. Here we review strategies to couple QDs to CPPs, by either covalent linkages or noncovalent interactions, to provide a tool to study intracellular delivery. This facilitated transport of QDs by CPPs into cells is both simple and efficient. Accordingly, CPP-QD nanoparticles are likely to be of broad utility in biological research and advance the development of medical and pharmaceutical therapeutics.
引用
收藏
页码：7897 / 7905
页数：9
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