Haploidentical Bone Marrow Transplantation in Primary Immune Deficiency: Stem Cell Selection and Manipulation

被引：3

作者：

Hagin, David ^{[1
]}

Reisner, Yair ^{[1
]}

机构：

[1] Weizmann Inst Sci, Dept Immunol, IL-76100 Rehovot, Israel

来源：

HEMATOLOGY-ONCOLOGY CLINICS OF NORTH AMERICA | 2011年 / 25卷 / 01期

关键词：

Immunodeficiency; Stem cell transplantation; T cell depletion; SEVERE COMBINED IMMUNODEFICIENCY; VERSUS-HOST-DISEASE; WISKOTT-ALDRICH-SYNDROME; RED-BLOOD-CELLS; SOYBEAN AGGLUTININ; THYMIC FUNCTION; SPLEEN-CELLS; IN-VITRO; LYMPHOCYTE ANTIBODY; MYELOID-LEUKEMIA;

D O I：

10.1016/j.hoc.2010.11.004

中图分类号：

R73 [肿瘤学];

学科分类号：

100214 ;

摘要：

Since the early 1980s T-cell depletion has allowed haploidentical bone marrow transplantation to be performed in patients with primary immunodeficiency for whom a matched sibling donor was not available, without causing severe graft versus host disease (GVHD). This review article presents the available data in the literature on survival, GVHD, and immune reconstitution in different categories of patients, with special emphasis on the impact of different T-cell depletion methods.

引用

页码：45 / +

页数：19

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