Insulin promotes hepatocarcinoma tumorigenesis by up-regulating PKM2 expression

被引：4

作者：

Liu, Jingjing ^{[1
,2
]}

Zhi, Qiang ^{[3
]}

Liu, Yunpeng ^{[1
,2
]}

Wang, Ying ^{[1
]}

Chen, Linlin ^{[3
]}

Ke, Yuhao ^{[1
]}

Zeng, Lingsu ^{[1
]}

Wu, Xiaoling ^{[3
]}

Yang, Xiaoning ^{[1
,2
]}

Guleng, Bayasi ^{[1
,2
,3
,4
,5
,6
]}

Liu, Hao ^{[7
]}

Ren, Jianlin ^{[1
,2
,3
,4
,5
,6
]}

机构：

[1] Xiamen Univ, Zhongshan Hosp, Dept Gastroenterol, 201 Hubin South Rd, Xiamen 361004, Fujian, Peoples R China

[2] Xiamen Univ, Zhongshan Hosp, Xiamen Key Lab Intestinal Microbiome & Human Hlth, 201 Hubin South Rd, Xiamen 361004, Fujian, Peoples R China

[3] Xiamen Univ, Fac Clin Med, Sch Med, 168 Univ Rd, Xiamen 361005, Fujian, Peoples R China

[4] Xiamen Univ, Med Coll, Fac Clin Med, 168 Univ Rd, Xiamen 361005, Fujian, Peoples R China

[5] Xiamen Univ, Med Coll, Inst Mirobial Ecol, 168 Univ Rd, Xiamen 361005, Fujian, Peoples R China

[6] Xiamen Univ, Sch Med, Dept Digest Dis, 168 Univ Rd, Xiamen 361005, Fujian, Peoples R China

[7] Ningxia Med Univ, Gen Hosp, 804 Shengli St, Yinchuan 750004, Ningxia Hui Aut, Peoples R China

来源：

EXPERIMENTAL CELL RESEARCH | 2021年 / 408卷 / 02期

基金：

中国国家自然科学基金;

关键词：

Insulin; Pyruvate kinase M2; Interaction; Cell proliferation; Hepatocarcinoma; PYRUVATE-KINASE M2; GROWTH-FACTOR-I; DIABETES-MELLITUS; COLORECTAL-CANCER; RECEPTOR NUR77; NUCLEAR; TRANSLOCATION; RESISTANCE; BINDING; RISK;

D O I：

10.1016/j.yexcr.2021.112872

中图分类号：

R73 [肿瘤学];

学科分类号：

100214 ;

摘要：

Insulin, as a growth factor, can increase the risk of certain types of cancer. The present study showed that insulin promoted the proliferation of hepatocellular carcinoma cells in vitro and in vivo through pyruvate kinase M2 (PKM2), which is a rate-limiting enzyme in the process of glycolysis. Moreover, the expression of PKM2 was up-regulated by insulin at the posttranslational level in a nuclear orphan receptor TR3-dependent manner. In addition, insulin could enhance the interaction between PKM2 and TR3 and protect PKM2 from degradation. Our results identified a specific mechanism of insulin affecting cancer metabolism and thus promoting cancer progression, and they contribute to a better understanding of the observation that insulin is linked to an increased cancer risk under hyperinsulinemic conditions.

引用

页数：10

共 46 条

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