Soluble Intercellular Adhesion Molecule- (sICAM-) 1, Thrombospondin-1, and Vinculin for the Identification of Septic Shock Patients Suffering from an Invasive Fungal Infection

被引:5
作者
Decker, Sebastian O. [1 ]
Incamps, Anne [2 ]
Sigl, Annette [3 ]
Uhle, Florian [1 ]
Bruckner, Thomas [4 ]
Heininger, Alexandra [5 ]
Zimmermann, Stefan [5 ]
Hirtz, Christophe [6 ]
Weigand, Markus A. [1 ]
Brenner, Thorsten [1 ]
机构
[1] Heidelberg Univ Hosp, Dept Anesthesiol, Heidelberg, Germany
[2] Thermo Fisher Sci Cezanne SAS, Clin Diagnost Div, Nimes, France
[3] RoMed Klinikum Rosenheim, Dept Gynaecol & Obstet, Rosenheim, Germany
[4] Heidelberg Univ, Inst Med Biometry & Informat, Heidelberg, Germany
[5] Heidelberg Univ Hosp, Dept Infect Dis Med Microbiol & Hyg, Heidelberg, Germany
[6] Montpellier Univ, CHU Montpellier, INSERM, LBPC PPC IRMB, Montpellier, France
关键词
CRITICALLY-ILL PATIENTS; INTENSIVE-CARE-UNIT; SEVERE SEPSIS; SERUM (1,3)-BETA-D-GLUCAN; CANDIDA-ALBICANS; MANAGEMENT; DIAGNOSIS; EPIDEMIOLOGY; EXPRESSION; CONSENSUS;
D O I
10.1155/2020/3470163
中图分类号
Q2 [细胞生物学];
学科分类号
071009 ; 090102 ;
摘要
Background. Nowadays, invasive fungal infections (IFI) are of increasing importance and associated with an increased mortality. However, reliable diagnostic tools for the identification of patients suffering from an IFI are rare and associated with relevant weaknesses. Methods. Within this secondary analysis of an observational clinical study, an innovative biomarker panel (consisting of 62 biomarkers in total) was screened for the identification of septic shock patients suffering from an IFI. Fungal growth in blood cultures, intraoperative swabs, and Aspergillus spp. in deep respiratory tract specimens with accompanying pulmonary infiltrates were classified as infection, whereas Candida spp. in the respiratory tract or in fluids from drainages were classified as colonization. Plasma samples of 50 septic shock patients at six predefined timepoints within a period of 28 days following the onset of septic shock were available. Results. In total, 11 out of the 50 patients (22%) were shown to suffer from an IFI, whereas 22 patients (44%) presented with a fungal colonization. Within the presented biomarker panel, plasma levels of soluble intercellular adhesion molecule- (sICAM-) 1, thrombospondin-1, and vinculin were shown to be the most promising. sICAM-1 was shown to be increased in patients with an IFI, whereas thrombospondin-1 and vinculin revealed decreased plasma levels as compared to colonized patients as well as patients without any fungal findings at any time. Conclusion. Plasmatic measurements of sICAM-1, thrombospondin-1, and vinculin may help to facilitate the diagnosis of an IFI in human septic shock and to identify patients with an increased risk for an IFI. This trial is registered with DRKS00005463.
引用
收藏
页数:13
相关论文
共 66 条
  • [21] DiPietro LA, 1996, AM J PATHOL, V148, P1851
  • [22] Epidemiology of Candida species infections in critically ill non-immunosuppressed patients
    Eggimann, P
    Garbino, J
    Pittet, D
    [J]. LANCET INFECTIOUS DISEASES, 2003, 3 (11) : 685 - 702
  • [23] Intercellular adhesion molecule 1-dependent activation of interleukin 8 expression in Candida albicans-infected human gingival epithelial cells
    Egusa, H
    Nikawa, H
    Makihira, S
    Jewett, A
    Yatani, H
    Hamada, T
    [J]. INFECTION AND IMMUNITY, 2005, 73 (01) : 622 - 626
  • [24] Combined use of serum (1,3)-β-D-glucan and procalcitonin for the early differential diagnosis between candidaemia and bacteraemia in intensive care units
    Giacobbe, Daniele Roberto
    Mikulska, Malgorzata
    Tumbarello, Mario
    Furfaro, Elisa
    Spadaro, Marzia
    Losito, Angela Raffaella
    Mesini, Alessio
    De Pascale, Gennaro
    Marchese, Anna
    Bruzzone, Marco
    Pelosi, Paolo
    Mussap, Michele
    Molin, Alexandre
    Antonelli, Massimo
    Posteraro, Brunella
    Sanguinetti, Maurizio
    Viscoli, Claudio
    Del Bono, Valerio
    [J]. CRITICAL CARE, 2017, 21
  • [25] Significant correlation between thrombospondin 1 and serine proteinase expression in rheumatoid synovium
    GotisGraham, I
    Hogg, PJ
    McNeil, HP
    [J]. ARTHRITIS AND RHEUMATISM, 1997, 40 (10): : 1780 - 1787
  • [26] Management of invasive candidiasis and candidemia in adult non-neutropenic intensive care unit patients: Part I. Epidemiology and diagnosis
    Guery, Benoit P.
    Arendrup, Maiken C.
    Auzinger, Georg
    Azoulay, Elie
    Borges Sa, Marcio
    Johnson, Elizabeth M.
    Mueller, Eckhard
    Putensen, Christian
    Rotstein, Coleman
    Sganga, Gabriele
    Venditti, Mario
    Zaragoza Crespo, Rafael
    Kullberg, Bart Jan
    [J]. INTENSIVE CARE MEDICINE, 2009, 35 (01) : 55 - 62
  • [27] Early blood-based microbiological testing is ineffective in severe stroke patients
    Gumbinger, Christoph
    Hug, Andreas
    Muerle, Bettina
    Berger, Benjamin
    Zorn, Markus
    Becker, Klaus-Peter
    Zimmermann, Stefan
    Dalpke, Alexander H.
    Veltkamp, Roland
    [J]. JOURNAL OF THE NEUROLOGICAL SCIENCES, 2013, 325 (1-2) : 46 - 50
  • [28] Vinculin and Rab5 Complex Is Requited for Uptake of Staphyrococcus aureus and Interleukin-6 Expression
    Hagiwara, Makoto
    Kokubu, Eitoyo
    Sugiura, Shinsuke
    Komatsu, Toshinori
    Tada, Hiroyuki
    Isoda, Ryutaro
    Tanigawa, Naomi
    Kato, Yoshiko
    Ishida, Naoyuki
    Kobayashi, Kaoru
    Nakashima, Misako
    Ishihara, Kazuyuki
    Matsushita, Kenji
    [J]. PLOS ONE, 2014, 9 (01):
  • [29] THROMBOSPONDIN BINDS TO STAPHYLOCOCCUS-AUREUS AND PROMOTES STAPHYLOCOCCAL ADHERENCE TO SURFACES
    HERRMANN, M
    SUCHARD, SJ
    BOXER, LA
    WALDVOGEL, FA
    LEW, PD
    [J]. INFECTION AND IMMUNITY, 1991, 59 (01) : 279 - 288
  • [30] Impact of biological matrix on inflammatory protein biomarker quantification based on targeted mass spectrometry
    Incamps, Anne
    Saez-Boiteau, Celia
    Tiede, Svenja Lena
    Rebillard, Pauline
    Schulte, Janin
    Vialaret, Jerome
    Beinrucker, Andre
    Lehmann, Sylvain
    Hirt, Christophe
    [J]. BIOANALYSIS, 2018, 10 (17) : 1383 - 1399