Factors Associated With Newly HIV Infection and Transmitted Drug Resistance Among Men Who Have Sex With Men in Harbin, PR China

被引：4

作者：

Hui, Shan ^{[1
,2
]}

Chen, Fangfang ^{[3
]}

Li, Yi ^{[2
]}

Cui, Yan ^{[3
]}

Zhang, Jinhui ^{[4
]}

Zhang, Ling ^{[5
]}

Yang, Yisi ^{[5
]}

Liu, Yanlin ^{[5
]}

Zhao, Yashuang ^{[1
]}

Lv, Fan ^{[3
]}

机构：

[1] Harbin Med Univ, Coll Publ Hlth, Dept Epidemiol, Harbin, Peoples R China

[2] Heilongjiang Prov Ctr Dis Control & Prevent, Harbin, Peoples R China

[3] Chinese Ctr Dis Control & Prevent, Beijing, Peoples R China

[4] Jixi Municipal Ctr Dis Control & Prevent, Harbin, Peoples R China

[5] Harbin Municipal Ctr Dis Control & Prevent, Harbin, Peoples R China

来源：

FRONTIERS IN PUBLIC HEALTH | 2022年 / 10卷

关键词：

HIV; MSM; incidence; drug resistance; seroconversion; PREVALENCE; MSM;

D O I：

10.3389/fpubh.2022.860171

中图分类号：

R1 [预防医学、卫生学];

学科分类号：

1004 ; 120402 ;

摘要：

BackgroundThis study aimed to evaluate HIV incidence, factors associated with HIV incidence and transmitted drug resistance (TDR) among newly infected men who have sex with men (MSM) in Harbin, P.R. China. MethodsA cohort study was conducted among MSM in Harbin during 2013 and 2018, with a follow-up frequency of every 6 months. Blood samples from MSM were tested for HIV antibodies, RNA was extracted from plasma, and the pol gene was sequenced, and genotypic drug-resistance analyses were performed. ResultsFrom 2013 to 2018, the overall rate of HIV incidence was 3.55/100 PY. Syphilis infection, unprotected sex with men in the past 6 months, and unawareness of HIV/AIDS knowledge were risk factors for HIV seroconversion. The distribution of HIV genotypes was as follows: CRF01_AE, 57.1%; CRF07_BC, 28.5%; CRF55_01B, 2.0%; B, 8.2%. The prevalence of transmitted drug resistance was 4.08%. ConclusionHIV incidence in MSM in Harbin is moderately high, and transmitted drug resistance exists in the population.

引用

页数：11

共 41 条

[1]

[Anonymous], 2012, CHIN J PUBLIC HLTH, DOI DOI 10.19568/J.CNKI.23-1318.2012.04.005

[2] Sanger and Next Generation Sequencing Approaches to Evaluate HIV-1 Virus in Blood Compartments [J].

Arias, Andrea ;

Lopez, Pablo ;

Sanchez, Raphael ;

Yamamura, Yasuhiro ;

Rivera-Amill, Vanessa .

INTERNATIONAL JOURNAL OF ENVIRONMENTAL RESEARCH AND PUBLIC HEALTH, 2018, 15 (08)

[3] Drug Resistance Mutations for Surveillance of Transmitted HIV-1 Drug-Resistance: 2009 Update [J].

Bennett, Diane E. ;

Camacho, Ricardo J. ;

Otelea, Dan ;

Kuritzkes, Daniel R. ;

Fleury, Herve ;

Kiuchi, Mark ;

Heneine, Walid ;

Kantor, Rami ;

Jordan, Michael R. ;

Schapiro, Jonathan M. ;

Vandamme, Anne-Mieke ;

Sandstrom, Paul ;

Boucher, Charles A. B. ;

van de Vijver, David ;

Rhee, Soo-Yon ;

Liu, Tommy F. ;

Pillay, Deenan ;

Shafer, Robert W. .

PLOS ONE, 2009, 4 (03)

[4] Drug resistance mutations in HIV: new bioinformatics approaches and challenges [J].

Blassel, Luc ;

Zhukova, Anna ;

Villabona-Arenas, Christian J. ;

Atkins, Katherine E. ;

Hue, Stephane ;

Gascuel, Olivier .

CURRENT OPINION IN VIROLOGY, 2021, 51 :56-64

[5] Increased antiretroviral therapy prescription and HIV viral suppression among persons receiving clinical care for HIV infection [J].

Bradley, Heather ;

Mattson, Christine L. ;

Beer, Linda ;

Huang, Ping ;

Shouse, R. Luke .

AIDS, 2016, 30 (13) :2117-2124

[6] Estimation of HIV Incidence Using Multiple Biomarkers [J].

Brookmeyer, Ron ;

Konikoff, Jacob ;

Laeyendecker, Oliver ;

Eshleman, Susan H. .

AMERICAN JOURNAL OF EPIDEMIOLOGY, 2013, 177 (03) :264-272

[7] Transmitted Drug Resistance and Phylogenetic Relationships Among Acute and Early HIV-1-Infected Individuals in New York City [J].

Castor, Delivette ;

Low, Andrea ;

Evering, Teresa ;

Karmon, Sharon ;

Davis, Brandi ;

Figueroa, Amir ;

LaMar, Melissa ;

Garmon, Donald ;

Mehandru, Saurabh ;

Markowitz, Martin .

JAIDS-JOURNAL OF ACQUIRED IMMUNE DEFICIENCY SYNDROMES, 2012, 61 (01) :1-8

[8] HIV-1 genetic diversity and recombinant forms among men who have sex with men at a sentinel surveillance site in Xi'an City, China [J].

Chang, Wenhui ;

Zhang, Mengyan ;

Ren, Qiang ;

Zou, Yangfan ;

Dong, Lifang ;

Jia, Hua ;

Liu, Feng .

INFECTION GENETICS AND EVOLUTION, 2020, 81

[9] HIV-1 genetic transmission networks among men who have sex with men in Kunming, China [J].

Chen, Min ;

Ma, Yanling ;

Chen, Huichao ;

Dai, Jie ;

Dong, Lijuan ;

Yang, Chaojun ;

Li, Youfang ;

Luo, Hongbing ;

Zhang, Renzhong ;

Jin, Xiaomei ;

Yang, Li ;

Cheung, Allen Ka Loon ;

Jia, Manhong ;

Song, Zhizhong .

PLOS ONE, 2018, 13 (04)

[10]

Chun Helen M, 2013, J Sex Transm Dis, V2013, P176459, DOI 10.1155/2013/176459

← 1 2 3 4 5 →