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Univ Bari, Dept Clin Methodol & Medicosurg Technol, Inst Internal Med & Hypertens,Oxygen Transport &, Res Ctr Hemorheol Microcirculat, I-70121 Bari, Italy Univ Bari, Dept Clin Methodol & Medicosurg Technol, Inst Internal Med & Hypertens,Oxygen Transport &, Res Ctr Hemorheol Microcirculat, I-70121 Bari, Italy