Isolation and absolute configuration of SMTP-0, a simplest congener of the SMTP family nonlysine-analog plasminogen modulators

被引：24

作者：

Hasumi, Keiji ^{[1
]}

Hasegawa, Keiko ^{[1
]}

Kitano, Yoshikazu ^{[1
]}

机构：

[1] Tokyo Noko Univ, Dept Appl Biol Sci, Fuchu, Tokyo 1838509, Japan

来源：

JOURNAL OF ANTIBIOTICS | 2007年 / 60卷 / 07期

关键词：

nonlysine-analog plasminogen modulator; absolute configuration; Stachybotrys microspora; microbial triprenyl phenols; modified Mosher method;

D O I：

10.1038/ja.2007.60

中图分类号：

Q81 [生物工程学（生物技术）]; Q93 [微生物学];

学科分类号：

071005 ; 0836 ; 090102 ; 100705 ;

摘要：

SMTP-0, a new simple congener of the SMTP nonlysine-analog plasminogen modulators, was isolated from a culture of Stachybotrys microspora. Based on the physico-chemical data, SMTP-O was shown to be an enantiomer of the antimicrobial compound stachybotrin B. The absolute configuration of SMTP-0 was determined by the modified Mosher method. The stereochemistry was further confirmed using an epimer of SMTP-O. Unlike most SMTPs with an amino acid side chain linked to the nitrogen atom of the lactam moiety, SMTP-0, which lacks the N-linked side chain, showed no plasminogen modulator activity.

引用

页码：463 / 468

页数：6

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