A New Flavone and Cytotoxic Constituents of Nicotiana tabacum

被引：12

作者：

Chien, Sheng-Kan ^{[1
]}

Chen, Lih-Chi ^{[2
,3
,4
]}

Huang, Hui-Chu ^{[5
]}

Chen, Li-Chai ^{[3
,6
]}

Hsiao, Jen-Wen ^{[7
]}

Cheng, Ming-Jen ^{[8
]}

Chen, Jih-Jung ^{[9
,10
]}

机构：

[1] Keelung City Municipal Hosp, Dept Pharm, Keelung 202, Taiwan

[2] Taipei City Hosp, Dept Pharm, Taipei 108, Taiwan

[3] Tajen Univ, Dept Pharm, Pingtung 907, Taiwan

[4] Natl United Univ, Ctr Gen Educ, Miaoli 360, Taiwan

[5] Kaohsiung Armed Forces Gen Hosp, Dept Resp Care, Zuoying Branch, Kaohsiung 813, Taiwan

[6] Kaohsiung Armed Forces Gen Hosp, Zuoying Branch, Dept Pharm, Kaohsiung 813, Taiwan

[7] Pingtung Christian Hosp, Dept Pharm, Pingtung 900, Taiwan

[8] FIRDI, BCRC, Hsinchu 300, Taiwan

[9] Natl Yang Ming Univ, Sch Pharmaceut Sci, Fac Pharm, Taipei 112, Taiwan

[10] China Med Univ Hosp, Dept Med Res, Taichung 404, Taiwan

来源：

CHEMISTRY OF NATURAL COMPOUNDS | 2018年 / 54卷 / 06期

关键词：

Nicotiana tabacum; Solanaceae; leaves; flavone; 8-formyl-7-hydroxy-6; 4-dimethoxyflavone; cytotoxic activity; MOSAIC-VIRUS ACTIVITIES; SESQUITERPENE GLUCOSIDES; LEAVES; TOBACCO; IDENTIFICATION;

D O I：

10.1007/s10600-018-2551-4

中图分类号：

R914 [药物化学];

学科分类号：

100701 ;

摘要：

A new flavone, 8-formyl-7-hydroxy-6,4-dimethoxyflavone (1), has been isolated from the leaves of Nicotiana tabacum, together with five known compounds, 8-formyl-4-hydroxy-6,7-dimethoxyflavone (2), quercetin (3), (2R,3R)-3,5-dihydroxy-7-methoxyflavanone (4), kaempferol (5), and rutin (6). The structure of the new compound 1 was determined through spectroscopic and MS analyses. Among the isolates, 8-formyl-7-hydroxy-6,4-dimethoxyflavone (1) and 8-formyl-4-hydroxy-6,7-dimethoxyflavone (2) exhibited cytotoxicities, with IC50 values of 2.24 +/- 0.32 and 3.40 +/- 0.21 g/mL, respectively, against CCRF-CEM and P388D1 cell lines.

引用

页码：1044 / 1047

页数：4

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