No Influence of Overweight/Obesity on Exercise Lipid Oxidation: A Systematic Review

被引：14

作者：

Arad, Avigdor D. ^{[1
]}

Basile, Anthony J. ^{[1
]}

Albu, Jeanine ^{[1
]}

DiMenna, Fred J. ^{[1
,2
]}

机构：

[1] Icahn Sch Med Mt Sinai, Dept Med, Div Endocrinol, New York, NY 10029 USA

[2] Columbia Univ Teachers Coll, Dept Biobehav Sci, New York, NY 10027 USA

来源：

INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES | 2020年 / 21卷 / 05期

关键词：

exercise lipid oxidation; overweight; obesity; insulin signal transduction pathway; insulin resistance; type; 2; diabetes; intramuscular triglycerides; ENDURANCE-TRAINED MALES; HIGH-INTENSITY EXERCISE; FATTY-ACID-METABOLISM; MENSTRUAL-CYCLE PHASE; HUMAN SKELETAL-MUSCLE; SUBSTRATE UTILIZATION; INSULIN-RESISTANCE; NORMAL-WEIGHT; MODERATE-INTENSITY; BODY-FAT;

D O I：

10.3390/ijms21051614

中图分类号：

Q5 [生物化学]; Q7 [分子生物学];

学科分类号：

071010 ; 081704 ;

摘要：

Compared to lean counterparts, overweight/obese individuals rely less on lipid during fasting. This deficiency has been implicated in the association between overweight/obesity and blunted insulin signaling via elevated intramuscular triglycerides. However, the capacity for overweight/obese individuals to use lipid during exercise is unclear. This review was conducted to formulate a consensus regarding the influence of overweight/obesity on exercise lipid use. PubMed, ProQuest, ISI Web of Science, and Cochrane Library databases were searched. Articles were included if they presented original research on the influence of overweight/obesity on exercise fuel use in generally healthy sedentary adults. Articles were excluded if they assessed older adults, individuals with chronic disease, and/or exercise limitations or physically-active individuals. The search identified 1205 articles with 729 considered for inclusion after duplicate removal. Once titles, abstracts, and/or manuscripts were assessed, 24 articles were included. The preponderance of evidence from these articles indicates that overweight/obese individuals rely on lipid to a similar extent during exercise. However, conflicting findings were found in eight articles due to the outcome measure cited, participant characteristics other than overweight/obesity and characteristics of the exercise bout(s). We also identified factors other than body fatness which can influence exercise lipid oxidation that should be controlled in future research.

引用

页数：32

共 119 条

[21] Abdominal fat and insulin resistance in normal and overweight women - Direct measurements reveal a strong relationship in subjects at both low and high risk of NIDDM [J].

Carey, DG ;

Jenkins, AB ;

Campbell, LV ;

Freund, J ;

Chisholm, DJ .

DIABETES, 1996, 45 (05) :633-638

[22] Adipose tissue lipolysis is upregulated in lean and obese men during acute resistance exercise [J].

Chatzinikolaou, Athanasios ;

Fatouros, Ioannis ;

Petridou, Anatoli ;

Jamurtas, Athanasios ;

Avloniti, Alexandra ;

Douroudos, Ioannis ;

Mastorakos, George ;

Lazaropoulou, Christina ;

Papassotiriou, Ioannis ;

Tournis, Symeon ;

Mitrakou, Asimina ;

Mougios, Vassilis .

DIABETES CARE, 2008, 31 (07) :1397-1399

[23]

Chitwood LF, 1996, INT J OBESITY, V20, P455

[24] Fat metabolism during high-intensity exercise in endurance-trained and untrained men [J].

Coggan, AR ;

Raguso, CA ;

Gastaldelli, A ;

Sidossis, LS ;

Yeckel, CW .

METABOLISM-CLINICAL AND EXPERIMENTAL, 2000, 49 (01) :122-128

[25] Utilization of glycogen but not plasma glucose is reduced in individuals with NIDDM during mild-intensity exercise [J].

Colberg, SR ;

Hagberg, JM ;

McCole, SD ;

Zmuda, JM ;

Thompson, PD ;

Kelley, DE .

JOURNAL OF APPLIED PHYSIOLOGY, 1996, 81 (05) :2027-2033

[26] EFFECT OF ADRENALINE INFUSION ON FATTY-ACID AND GLUCOSE-TURNOVER IN LEAN AND OBESE HUMAN-SUBJECTS IN THE POST-ABSORPTIVE AND FED STATES [J].

CONNACHER, AA ;

BENNET, WM ;

JUNG, RT ;

BIER, DM ;

SMITH, CCT ;

SCRIMGEOUR, CM ;

RENNIE, MJ .

CLINICAL SCIENCE, 1991, 81 (05) :635-644

[27] LIPID-METABOLISM IN SKELETAL-MUSCLE OF ENDURANCE-TRAINED MALES AND FEMALES [J].

COSTILL, DL ;

FINK, WJ ;

GETCHELL, LH ;

IVY, JL ;

WITZMANN, FA .

JOURNAL OF APPLIED PHYSIOLOGY, 1979, 47 (04) :787-791

[28] Racial Differences In Peripheral Insulin Sensitivity and Mitochondrial Capacity in the Absence of Obesity [J].

DeLany, James P. ;

Dube, John J. ;

Standley, Robert A. ;

Distefano, Giovanna ;

Goodpaster, Bret H. ;

Stefanovic-Racic, Maja ;

Coen, Paul M. ;

Toledo, Frederico G. S. .

JOURNAL OF CLINICAL ENDOCRINOLOGY & METABOLISM, 2014, 99 (11) :4307-4314

[29] Menstrual cycle phase and sex influence muscle glycogen utilization and glucose turnover during moderate-intensity endurance exercise [J].

Devries, Michaela C. ;

Hamadeh, Mazen J. ;

Phillips, Stuart M. ;

Tarnopolsky, Mark A. .

AMERICAN JOURNAL OF PHYSIOLOGY-REGULATORY INTEGRATIVE AND COMPARATIVE PHYSIOLOGY, 2006, 291 (04) :R1120-R1128

[30] Endurance Training Modulates Intramyocellular Lipid Compartmentalization and Morphology in Skeletal Muscle of Lean and Obese Women [J].

Devries, Michaela C. ;

Samjoo, Imtiaz A. ;

Hamadeh, Mazen J. ;

McCready, Colin ;

Raha, Sandeep ;

Watt, Matthew J. ;

Steinberg, Gregory R. ;

Tarnopolsky, Mark A. .

JOURNAL OF CLINICAL ENDOCRINOLOGY & METABOLISM, 2013, 98 (12) :4852-4862

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