No Influence of Overweight/Obesity on Exercise Lipid Oxidation: A Systematic Review

被引：14

作者：

Arad, Avigdor D. ^{[1
]}

Basile, Anthony J. ^{[1
]}

Albu, Jeanine ^{[1
]}

DiMenna, Fred J. ^{[1
,2
]}

机构：

[1] Icahn Sch Med Mt Sinai, Dept Med, Div Endocrinol, New York, NY 10029 USA

[2] Columbia Univ Teachers Coll, Dept Biobehav Sci, New York, NY 10027 USA

来源：

INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES | 2020年 / 21卷 / 05期

关键词：

exercise lipid oxidation; overweight; obesity; insulin signal transduction pathway; insulin resistance; type; 2; diabetes; intramuscular triglycerides; ENDURANCE-TRAINED MALES; HIGH-INTENSITY EXERCISE; FATTY-ACID-METABOLISM; MENSTRUAL-CYCLE PHASE; HUMAN SKELETAL-MUSCLE; SUBSTRATE UTILIZATION; INSULIN-RESISTANCE; NORMAL-WEIGHT; MODERATE-INTENSITY; BODY-FAT;

D O I：

10.3390/ijms21051614

中图分类号：

Q5 [生物化学]; Q7 [分子生物学];

学科分类号：

071010 ; 081704 ;

摘要：

Compared to lean counterparts, overweight/obese individuals rely less on lipid during fasting. This deficiency has been implicated in the association between overweight/obesity and blunted insulin signaling via elevated intramuscular triglycerides. However, the capacity for overweight/obese individuals to use lipid during exercise is unclear. This review was conducted to formulate a consensus regarding the influence of overweight/obesity on exercise lipid use. PubMed, ProQuest, ISI Web of Science, and Cochrane Library databases were searched. Articles were included if they presented original research on the influence of overweight/obesity on exercise fuel use in generally healthy sedentary adults. Articles were excluded if they assessed older adults, individuals with chronic disease, and/or exercise limitations or physically-active individuals. The search identified 1205 articles with 729 considered for inclusion after duplicate removal. Once titles, abstracts, and/or manuscripts were assessed, 24 articles were included. The preponderance of evidence from these articles indicates that overweight/obese individuals rely on lipid to a similar extent during exercise. However, conflicting findings were found in eight articles due to the outcome measure cited, participant characteristics other than overweight/obesity and characteristics of the exercise bout(s). We also identified factors other than body fatness which can influence exercise lipid oxidation that should be controlled in future research.

引用

页数：32

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