Synthesis and biological profile of substituted benzimidazoles

被引：7

作者：

Vashist, Neelam ^{[1
]}

Sambi, Surinder Singh ^{[2
]}

Narasimhan, Balasubramanian ^{[3
]}

Kumar, Sanjiv ^{[3
]}

Lim, Siong Meng ^{[4
,5
]}

Shah, Syed Adnan Ali ^{[4
,6
]}

Ramasamy, Kalavathy ^{[4
,5
]}

Mani, Vasudevan ^{[7
]}

机构：

[1] Shree Guru Gobind Singh Tricentenary SGT Univ, SGT Coll Pharm, Gurugram 122505, India

[2] Guru Gobind Singh Indraprastha Univ, Univ Sch Chem Technol, Sect 16C, New Delhi 110078, India

[3] Maharshi Dayanand Univ, Fac Pharmaceut Sci, Rohtak 124001, Haryana, India

[4] Univ Teknol MARA UiTM, Fac Pharm, Bandar Puncak Alam 42300, Selangor Darul, Malaysia

[5] Univ Teknol MARA UiTM, Pharmaceut Life Sci Community Res, Collaborat Drug Discovery Res CDDR Grp, Shah Alam 40450, Selangor Darul, Malaysia

[6] Univ Teknol MARA, Atta ur Rahman Inst Nat Prod Discovery AuRIns, Puncak Alam Campus, Bandar Puncak Alam 42300, Selangor Darul, Malaysia

[7] Qassim Univ, Coll Pharm, Dept Pharmacol & Toxicol, Buraydah 51452, Saudi Arabia

来源：

CHEMISTRY CENTRAL JOURNAL | 2018年 / 12卷

关键词：

Benzimidazoles; Synthesis; Antimicrobial activity; Anticancer activity; ANTIMICROBIAL ACTIVITY; DERIVATIVES; SERIES;

D O I：

10.1186/s13065-018-0498-y

中图分类号：

O6 [化学];

学科分类号：

0703 ;

摘要：

BackgroundA series of benzimidazole derivatives was developed and its chemical scaffolds were authenticated by NMR, IR, elemental analyses and physicochemical properties. The synthesized compounds were screened for their antimicrobial and antiproliferative activities.Results and discussionThe synthesized benzimidazole compounds were evaluated for their antimicrobial activity using the tube dilution method and were found to exhibit good antimicrobial potential against selected Gram negative and positive bacterial and fungal species. The compounds were also assessed for their anticancer activity exhibited using the SRB assay and were found to elicit antiproliferative activity against MCF7 breast cancer cell line, which was comparable to the standard drug.ConclusionAntimicrobial screening results indicated thatcompounds 1, 2 and 19 to be promising antimicrobial agents against selected microbial species and comparable to standard drugs which included norfloxacin and fluconazole. The anticancer screening results revealed that compounds, 12, 21, 22 and 29 to show the highest activity against MCF7 and their IC50 values were more potent than 5-fluorouracil.

引用

页数：12

共 16 条

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