Liposomal honokiol promotes hair growth via activating Wnt3a/β-catenin signaling pathway and down regulating TGF-β1 in C57BL/6N mice

被引：27

作者：

Li, Shenglan ^{[1
]}

Chen, Jinyi ^{[1
]}

Chen, Feng ^{[1
]}

Wang, Ce ^{[1
]}

Guo, Xiaodi ^{[1
]}

Wang, Can ^{[1
]}

Fan, Yaqiong ^{[1
]}

Wang, Yali ^{[1
]}

Peng, Yichen ^{[1
]}

Li, Wenbin ^{[1
]}

机构：

[1] Capital Med Univ, Beijing Tiantan Hosp, Canc Ctr, Dept Neurooncol, Beijing 100071, Peoples R China

来源：

BIOMEDICINE & PHARMACOTHERAPY | 2021年 / 141卷

关键词：

Hair growth; Liposomal honokiol; Wnt3a; beta-catenin; TGF-beta; 1; Hair cycle; STEM-CELLS; FOLLICLE MORPHOGENESIS; APOPTOSIS; PROLIFERATION;

D O I：

10.1016/j.biopha.2021.111793

中图分类号：

R-3 [医学研究方法]; R3 [基础医学];

学科分类号：

1001 ;

摘要：

Liposomal honokiol isolated from the genus Magnolia has been found to have antiangiogenic, anti-inflammatory and antitumor properties. However, there has no report on its role in hair growth. Hair follicles are life-long cycled organelles that go through from anagen, catagen and telogen stages and are regulated by diverse signaling pathways, including Wnt/beta-catenin, Notch, Epidermal growth factor (EGF) and Sonic hegehog (SHH). Wnt signals are essential for the initiation of hair follicle placode development and a new potential target of hair loss treatment. This study was designed to investigate the effect of liposomal honokiol (Lip-honokiol) on inducing hair anagen. We identified the hair grew out in advance in the shaving area of C57BL/6N mice after the treatment of liposomal honokiol (Lip-honokiol) by daily abdominal injection. We first demonstrated that Lip-Honokiol activated the Wnt3a/beta-catenin pathway and downregulated the transforming growth factor-beta 1 (TGF-beta 1) to promote hair growth in mice via immunohistochemistry and immunofluorescence staining. These findings suggest that Lip-honokiol activated the Wnt/beta-catenin pathway and accelerated the transfer from the telogen to anagen stage and finally promoted the hair growth.

引用

页数：9

共 34 条

[1] WNT signals are required for the initiation of hair follicle development [J].