Biocompatible iron(iii) carboxylate metal-organic frameworks as promising RNA nanocarriers

被引：55

作者：

Hidalgo, T. ^{[1
,2
]}

Alonso-Nocelo, M. ^{[3
,4
]}

Bouzo, B. L. ^{[3
,5
]}

Reimondez-Troitino, S. ^{[3
,5
]}

Abuin-Redondo, C. ^{[3
]}

de la Fuente, M. ^{[3
,4
]}

Horcajada, P. ^{[1
,2
]}

机构：

[1] IMDEA Energy Inst, APMU, Ave Ramon Sagra 3, Mostoles Madrid 28935, Spain

[2] Univ Versailles St Quentin En Yvelines, UMR CNRS8180, Inst Lavoisier, 45 Ave Etats Unis, F-78035 Versailles, France

[3] Clin Univ Hosp Santiago de Compostela CHUS, Hlth Res Inst Santiago de Compostela IDIS, Nanooncol Unit, Santiago De Compostela 15706, Spain

[4] Univ Santiago de Compostela, Ctr Res Mol Med & Chron Dis CIMUS, Campus Vida, Santiago De Compostela, Spain

[5] Canc Network Res CIBERONC, Madrid 28029, Spain

来源：

NANOSCALE | 2020年 / 12卷 / 08期

关键词：

IN-VITRO; OVARIAN-CANCER; POOLED SIRNAS; NANOPARTICLES; DELIVERY; CYTOTOXICITY; MIL-100(FE); RESISTANCE; MOF; DNA;

D O I：

10.1039/c9nr08127e

中图分类号：

O6 [化学];

学科分类号：

0703 ;

摘要：

Despite the great interest in RNA therapeutics, the development of a successful gene delivery process is still a major challenge. We propose an efficient nucleic acid entrapment into the mesopores of biocompatible nanoscaled metal-organic frameworks. Their rapid cellular uptake together with RNA protection and release led to a relevant in vitro gene activity.

引用

页码：4839 / 4845

页数：7

共 45 条

[21] Filleur S, 2003, CANCER RES, V63, P3919
[22] The role of surface charge in cellular uptake and cytotoxicity of medical nanoparticles
Froehlich, Eleonore
[J]. INTERNATIONAL JOURNAL OF NANOMEDICINE, 2012, 7 : 5577 - 5591
[23] MicroRNAs in Soft Tissue Sarcomas: Overview of the Accumulating Evidence and Importance as Novel Biomarkers
Fujiwara, Tomohiro
Kunisada, Toshiyuki
Takeda, Ken
Uotani, Koji
Yoshida, Aki
Ochiya, Takahiro
Ozaki, Toshifumi
[J]. BIOMED RESEARCH INTERNATIONAL, 2014, 2014
[24] In vitro biocompatibility of mesoporous metal (III; Fe, Al, Cr) trimesate MOF nanocarriers
Grall, Romain
Hidalgo, Tania
Delic, Jozo
Garcia-Marquez, Alfonso
Chevillard, Sylvie
Horcajada, Patricia
[J]. JOURNAL OF MATERIALS CHEMISTRY B, 2015, 3 (42) : 8279 - 8292
[25] Nanoscale Metal-Organic Frameworks for the Co-Delivery of Cisplatin and Pooled siRNAs to Enhance Therapeutic Efficacy in Drug-Resistant Ovarian Cancer Cells
He, Chunbai
Lu, Kuangda
Liu, Demin
Lin, Wenbin
[J]. JOURNAL OF THE AMERICAN CHEMICAL SOCIETY, 2014, 136 (14) : 5181 - 5184
[26] Functional Nanostructures for Effective Delivery of Small Interfering RNA Therapeutics
Hong, Cheol Am
Nam, Yoon Sung
[J]. THERANOSTICS, 2014, 4 (12): : 1211 - 1232
[27] Synthesis and catalytic properties of MIL-100(Fe), an iron(III) carboxylate with large pores
Horcajada, Patricia
Surble, Suzy
Serre, Christian
Hong, Do-Young
Seo, You-Kyong
Chang, Jong-San
Greneche, Jean-Marc
Margiolaki, Irene
Ferey, Gerard
[J]. CHEMICAL COMMUNICATIONS, 2007, (27) : 2820 - 2822
[28] Extended and functionalized porous iron(III) tri- or dicarboxylates with MIL-100/101 topologies
Horcajada, Patricia
Chevreau, Hubert
Heurtaux, Daniela
Benyettou, Farah
Salles, Fabrice
Devic, Thomas
Garcia-Marquez, Alfonso
Yu, Cihang
Lavrard, Hubert
Dutson, Claire L.
Magnier, Emmanuel
Maurin, Guillaume
Elkaim, Erik
Serre, Christian
[J]. CHEMICAL COMMUNICATIONS, 2014, 50 (52) : 6872 - 6874
[29] Horcajada P, 2010, NAT MATER, V9, P172, DOI [10.1038/NMAT2608, 10.1038/nmat2608, 10.1038/NMAT260B]
[30] Infrared study of the influence of reducible iron(III) metal sites on the adsorption of CO, CO2, propane, propene and propyne in the mesoporous metal-organic framework MIL-100
Leclerc, Herve
Vimont, Alexandre
Lavalley, Jean-Claude
Daturi, Marco
Wiersum, Andrew D.
Llwellyn, Philip L.
Horcajada, Patricia
Ferey, Gerard
Serre, Christian
[J]. PHYSICAL CHEMISTRY CHEMICAL PHYSICS, 2011, 13 (24) : 11748 - 11756

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