Biocompatible iron(iii) carboxylate metal-organic frameworks as promising RNA nanocarriers

被引：58

作者：

Hidalgo, T. ^{[1
,2
]}

Alonso-Nocelo, M. ^{[3
,4
]}

Bouzo, B. L. ^{[3
,5
]}

Reimondez-Troitino, S. ^{[3
,5
]}

Abuin-Redondo, C. ^{[3
]}

de la Fuente, M. ^{[3
,4
]}

Horcajada, P. ^{[1
,2
]}

机构：

[1] IMDEA Energy Inst, APMU, Ave Ramon Sagra 3, Mostoles Madrid 28935, Spain

[2] Univ Versailles St Quentin En Yvelines, UMR CNRS8180, Inst Lavoisier, 45 Ave Etats Unis, F-78035 Versailles, France

[3] Clin Univ Hosp Santiago de Compostela CHUS, Hlth Res Inst Santiago de Compostela IDIS, Nanooncol Unit, Santiago De Compostela 15706, Spain

[4] Univ Santiago de Compostela, Ctr Res Mol Med & Chron Dis CIMUS, Campus Vida, Santiago De Compostela, Spain

[5] Canc Network Res CIBERONC, Madrid 28029, Spain

来源：

NANOSCALE | 2020年 / 12卷 / 08期

关键词：

IN-VITRO; OVARIAN-CANCER; POOLED SIRNAS; NANOPARTICLES; DELIVERY; CYTOTOXICITY; MIL-100(FE); RESISTANCE; MOF; DNA;

D O I：

10.1039/c9nr08127e

中图分类号：

O6 [化学];

学科分类号：

0703 ;

摘要：

Despite the great interest in RNA therapeutics, the development of a successful gene delivery process is still a major challenge. We propose an efficient nucleic acid entrapment into the mesopores of biocompatible nanoscaled metal-organic frameworks. Their rapid cellular uptake together with RNA protection and release led to a relevant in vitro gene activity.

引用

页码：4839 / 4845

页数：7

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