Association of Triglyceride to high-density lipoprotein cholesterol ratio and incident of diabetes mellitus: a secondary retrospective analysis based on a Chinese cohort study

被引:83
作者
Chen, Zhuangsen [1 ,2 ,3 ]
Hu, Haofei [3 ,4 ,5 ]
Chen, Miaoling [1 ,2 ,3 ]
Luo, Xueying [6 ]
Yao, Weili [7 ]
Liang, Qian [8 ]
Yang, Fan [1 ,2 ,3 ]
Wang, Xinyu [1 ,2 ,3 ]
机构
[1] Shenzhen Univ, Affiliated Hosp 1, Dept Endocrinol, 3002 Sungang Rd, Shenzhen 518000, Guangdong, Peoples R China
[2] Shenzhen Second Peoples Hosp, Dept Endocrinol, Shenzhen 518000, Guangdong, Peoples R China
[3] Shenzhen Univ, Hlth Sci Ctr, Shenzhen 518000, Guangdong, Peoples R China
[4] Shenzhen Univ, Dept Nephrol, Affiliated Hosp 1, Shenzhen 518000, Guangdong, Peoples R China
[5] Shenzhen Second Peoples Hosp, Dept Nephrol, Shenzhen 518000, Guangdong, Peoples R China
[6] Shenzhen Peoples Hosp, Dept Plast & Reconstruct, Shenzhen 518000, Guangdong, Peoples R China
[7] Shenzhen Longhua Dist Peoples Hosp, Dept Endocrinol, Shenzhen 518000, Guangdong, Peoples R China
[8] Shenzhen Peoples Hosp, Dept Endocrinol, Shenzhen 518000, Guangdong, Peoples R China
关键词
Triglycerides; High-density lipoprotein cholesterol; Incident diabetes; Nonlinearity; TG/HDL-C RATIO; INSULIN-RESISTANCE; RISK; INDIVIDUALS; PREDICTOR;
D O I
10.1186/s12944-020-01213-x
中图分类号
Q5 [生物化学]; Q7 [分子生物学];
学科分类号
071010 ; 081704 ;
摘要
Background Previous studies have revealed that triglyceride to high-density lipoprotein cholesterol ratio (TG/HDL-C) is one of major risk factors of insulin resistance and diabetes. However, study on the association between TG/HDL-C and diabetes mellitus (DM) risk is limited, especially in Chinese people. This study was undertaken to investigate the relationship between TG/HDL-C and incident of diabetes in a large cohort in Chinese population. Methods The present study was a retrospective cohort study. A total of 114,787 adults from Rich Healthcare Group in China, which includes all medical records for participants who received a health check from 2010 to 2016. The target independent variable and the dependent variable were triglyceride to high-density lipoprotein cholesterol ratio measured at baseline and incident of diabetes mellitus appeared during follow-up respectively. Covariates involved in this study included age, gender, body mass index, diastolic blood pressure, systolic blood pressure, fasting plasma glucose, total cholesterol, low density lipoprotein cholesterol, serum creatinine, smoking and drinking status and family history of diabetes. Cox proportional-hazards regression was used to investigate the association of TG/HDL-C and diabetes. Generalized additive models was used to identify non-linear relationships. Additionally, we also performed a subgroup analysis. It was stated that the data had been uploaded to the DATADRYAD website. Result After adjusting age, gender, body mass index, systolic blood pressure, diastolic blood pressure, fasting blood glucose, total cholesterol, low density lipoprotein cholesterol, serum creatinine, smoking and drinking status and family history of diabetes, result showed TG/HDL-C was positively associated with incident of diabetes mellitus (HR = 1.159, 95%CI (1.104, 1.215)). A non-linear relationship was detected between TG/HDL-C and incident of diabetes, which had an inflection point of TG/HDL-C was 1.186. The effect sizes and the confidence intervals on the left and right sides of the inflection point were 1.718(1.433,2.060) and 1.049(0.981,1.120), respectively. Subgroup analysis showed, the stronger association can be found in the population with fasting plasma glucose (FPG) < 6.1 mmol/L (P for interaction< 0.0001; HR = 1.296 with FPG < 6.1 mmol/L vs HR = 1.051 with FPG >= 6.1 mmol/L).The same trend was also seen in the population with body mass index (BMI)(>= 18.5, < 24 kg/m(2)) (P for interaction = 0.010,HR = 1.324) and family history without diabetes(P for interaction = 0.025, HR = 1.170). Conclusion TG/HDL-C is positively associated with diabetes risk. The relationship between TG/HDL-C and incident of diabetes is also non-linear. TG/HDL-C was strong positively related to incident of diabetes when TG/HDL-C is less than 1.186.
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页数:11
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