Stem and progenitor cell-based therapy approaches. Current developments on treatment of acute myocardial infarction and chronic ischemic cardiomyopathy

被引：0
作者：
Templin, C. [1 ]
Luescher, T. F. [1 ,2 ]
Landmesser, U. [1 ]
机构：
[1] Univ Spital Zurich, Kardiol Klin, CH-8091 Zurich, Switzerland
[2] Univ Zurich, Inst Physiol, Zurich, Switzerland
来源：
HERZ | 2010年 / 35卷 / 07期
关键词：
Stem cells; Progenitor cells; Myocardial infarction; Cardiomoypathy; lschemic heart disease; BONE-MARROW-CELLS; LEFT-VENTRICULAR FUNCTION; AUTOLOGOUS SKELETAL MYOBLASTS; MESENCHYMAL STROMAL CELLS; ENDOTHELIAL GROWTH-FACTOR; INTRACORONARY INJECTION; CARDIAC-FUNCTION; MONONUCLEAR-CELLS; HEART-FAILURE; FOLLOW-UP;
D O I：
10.1007/s00059-010-3397-0
中图分类号：
R5 [内科学];
学科分类号：
1002 ; 100201 ;
摘要：
Percutaneous coronary intervention (PCI) for coronary revascularization in conjunction with an optimized pharmacological treatment can reduce adverse left ventricular remodeling and dysfunction in patients with acute myocardial infarction. Despite these modern therapeutic strategies a significant number of these patients continue to develop adverse cardiac remodeling and LV dysfunction which is associated with a poor prognosis. Stem and progenitor cell-based approaches for treatment of acute myocardial infarction and chronic ischemic cardiomyopathy are an interesting direction of current experimental and clinical research. The current review article provides a summary of recent developments of cell-based therapies of ischemic heart disease, including the assessment of the repair and regeneration capacity of different stem and progenitor cell populations. In addition the advantages and disadvantages of different modes of cell application and potential strategies for the improvement of stem and progenitor cell function for their use in cell-based cardiovascular therapies will be described.
引用
收藏
页码：445 / +
页数：12
相关论文
共 138 条
  • [1] Adult bone marrow-derived cells for cardiac repair - A systematic review and meta-analysis
    Abdel-Latif, Ahmed
    Bolli, Roberto
    Tleyjeh, Imad M.
    Montori, Victor M.
    Perin, Emerson C.
    Hornung, Carlton A.
    Zuba-Surma, Ewa K.
    Al-Mallah, Mouaz
    Dawn, Buddhadeb
    [J]. ARCHIVES OF INTERNAL MEDICINE, 2007, 167 (10) : 989 - 997
  • [2] Evidence that the number of hematopoietic stem cells per animal is conserved in mammals
    Abkowitz, JL
    Catlin, SN
    McCallie, MT
    Guttorp, P
    [J]. BLOOD, 2002, 100 (07) : 2665 - 2667
  • [3] Assessment of the tissue distribution of transplanted human endothelial progenitor cells by radioactive labeling
    Aicher, A
    Brenner, W
    Zuhayra, M
    Badorff, C
    Massoudi, S
    Assmus, B
    Eckey, T
    Henze, E
    Zeiher, AM
    Dimmeler, S
    [J]. CIRCULATION, 2003, 107 (16) : 2134 - 2139
  • [4] Transplantation of progenitor cells and regeneration enhancement in acute myocardial infarction -: (TOPCARE-AMI)
    Assmus, B
    Schächinger, V
    Teupe, C
    Britten, M
    Lehmann, R
    Döbert, N
    Grünwald, F
    Aicher, A
    Urbich, C
    Martin, H
    Hoelzer, D
    Dimmeler, S
    Zeiher, AM
    [J]. CIRCULATION, 2002, 106 (24) : 3009 - 3017
  • [5] Clinical Outcome 2 Years After Intracoronary Administration of Bone Marrow-Derived Progenitor Cells in Acute Myocardial Infarction
    Assmus, Birgit
    Rolf, Andreas
    Erbs, Sandra
    Elsaesser, Albrecht
    Haberbosch, Werner
    Hambrecht, Rainer
    Tillmanns, Harald
    Yu, Jiangtao
    Corti, Roberto
    Mathey, Detlef G.
    Hamm, Christian W.
    Sueselbeck, Tim
    Tonn, Torsten
    Dimmeler, Stefanie
    Dill, Thorsten
    Zeiher, Andreas M.
    Schaechinger, Volker
    [J]. CIRCULATION-HEART FAILURE, 2010, 3 (01) : 89 - 96
  • [6] Systemic delivery of bone marrow-derived mesenchymal stem cells to the infarcted myocardium - Feasibility, cell migration, and body distribution
    Barbash, IM
    Chouraqui, P
    Baron, J
    Feinberg, MS
    Etzion, S
    Tessone, A
    Miller, L
    Guetta, E
    Zipori, D
    Kedes, LH
    Kloner, RA
    Leor, J
    [J]. CIRCULATION, 2003, 108 (07) : 863 - 868
  • [7] Intracoronary injection of CD133-positive enriched bone marrow progenitor cells promotes cardiac recovery after recent myocardial infarction - Feasibility and safety
    Bartunek, J
    Vanderheyden, M
    Vandekerckhove, B
    Mansour, S
    De Bruyne, B
    De Bondt, P
    Van Haute, I
    Lootens, N
    Heyndrickx, G
    Wijns, W
    [J]. CIRCULATION, 2005, 112 (09) : I178 - I183
  • [8] Adult cardiac stem cells are multipotent and support myocardial regeneration
    Beltrami, AP
    Barlucchi, L
    Torella, D
    Baker, M
    Limana, F
    Chimenti, S
    Kasahara, H
    Rota, M
    Musso, E
    Urbanek, K
    Leri, A
    Kajstura, J
    Nadal-Ginard, B
    Anversa, P
    [J]. CELL, 2003, 114 (06) : 763 - 776
  • [9] Bergmann MW, 2010, HERZ, V35, P317, DOI 10.1007/s00059-010-3358-7
  • [10] Embryonic and adult stem cell therapy
    Brignier, Anne C.
    Gewirtz, Alan M.
    [J]. JOURNAL OF ALLERGY AND CLINICAL IMMUNOLOGY, 2010, 125 (02) : S336 - S344
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