Single-nucleotide polymorphisms in selected cytokine genes and risk of adult glioma

被引：43

作者：

Brenner, A. V. ^{[1
]}

Butler, M. A.

Wang, S. S.

Ruder, A. M.

Rothman, N.

Schulte, P. A.

Chanock, S. J.

Fine, H. A.

Linet, M. S.

Inskip, P. D.

机构：

[1] NCI, NIH, Div Canc Epidemiol & Genet, Bethesda, MD 20892 USA

[2] NIOSH, CDC, DHHS, Div Appl Res & Technol, Cincinnati, OH 45226 USA

[3] NIOSH, CDC, DHHS, Div Surveillance Hazard Evaluat & Field Studi, Cincinnati, OH 45226 USA

[4] NIOSH, CDC, DHHS, Educ & Informat Div, Cincinnati, OH 45226 USA

[5] NCI, NIH, Adv Technol Corp, Core Genotyping Facil, Bethesda, MD 20892 USA

[6] NCI, NIH, DHHS, Ctr Canc Res, Bethesda, MD 20892 USA

来源：

CARCINOGENESIS | 2007年 / 28卷 / 12期

关键词：

D O I：

10.1093/carcin/bgm210

中图分类号：

R73 [肿瘤学];

学科分类号：

100214 ;

摘要：

A role of immunological factors in glioma etiology is suggested by reports of an inverse relationship with history of allergy or autoimmune disease. To test whether single-nucleotide polymorphisms (SNPs) in cytokine genes were related to risk of adult glioma, we genotyped 11 SNPs in seven cytokine genes within a hospital-based study conducted by the National Cancer Institute and an independent, population-based study by the National Institute for Occupational Safety and Health (overall 756 cases and 1190 controls with blood samples). The IL4 (rs2243248, -1098T > G) and IL6 (rs1800795, -174G > C) polymorphisms were significantly associated with risk of glioma in the pooled analysis (P trend = 0.006 and 0.04, respectively), although these became attenuated after controlling for the false discovery rate (P trend = 0.07 and 0.22, respectively). Our results underscore the importance of pooled analyses in genetic association studies and suggest that SNPs in cytokine genes may influence susceptibility to glioma.

引用

页码：2543 / 2547

页数：5

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