Nickel-catalyzed highly regioselective hydrocyanation of aliphatic allenes

被引：3
作者：
Ding, Ying [1 ]
Long, Jinguo [1 ]
Fang, Xianjie [1 ]
机构：
[1] Shanghai Jiao Tong Univ, Sch Chem & Chem Engn, Shanghai Key Lab Mol Engn Chiral Drugs, 800 Dongchuan Rd, Shanghai 200240, Peoples R China
来源：
ORGANIC CHEMISTRY FRONTIERS | 2021年 / 8卷 / 20期
关键词：
PHOSPHINE-PHOSPHITE LIGANDS; ASYMMETRIC HYDROCYANATION; HYDROGEN-CYANIDE; STEREOSELECTIVE HYDROCYANATION; AXIAL CHIRALITY; ALKENES; MARKOVNIKOV; OLEFINS; VINYLARENES; CYANATION;
D O I：
10.1039/d1qo01099a
中图分类号：
O62 [有机化学];
学科分类号：
070303 ; 081704 ;
摘要：
A nickel-catalyzed hydrocyanation of aliphatic allenes with excellent regioselectivity is developed. This protocol features mild reaction conditions and good functional group tolerance, providing an efficient catalytic pathway to access various allylic nitriles containing quaternary carbon centers in a one-step fashion. In addition, preliminarily attempts were made to investigate an asymmetric version of this reaction.
引用
收藏
页码：5852 / 5857
页数：6
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