The molecular genetics of arrhythmias and sudden death

被引:14
作者
Brugada, R
Roberts, R
机构
[1] Baylor Coll Med, Dept Cell Biol, Houston, TX 77030 USA
[2] Baylor Coll Med, Dept Med Cardiol, Houston, TX 77030 USA
关键词
genetics; sudden death;
D O I
10.1002/clc.4960210805
中图分类号
R5 [内科学];
学科分类号
1002 ; 100201 ;
摘要
The current status of the research in genetics of cardiac diseases causing sudden death is reviewed. Few techniques will impact medicine as will those of molecular biology. The identification of the gene-causing diseases will allow the use of better preventive, diagnostic, and therapeutic options. From genetic counseling at present to gene therapy in the future, the new challenge for the clinician will be to acquire the new information provided by molecular biology and apply it at the bedside to improve the quality of life for the patient.
引用
收藏
页码:553 / 560
页数:8
相关论文
共 25 条
[1]   Gene mapping of familial autosomal dominant dilated cardiomyopathy to chromosome 1Oq21-23 [J].
Bowles, KR ;
Gajarski, R ;
Porter, P ;
Goytia, V ;
Bachinski, L ;
Roberts, R ;
Pignatelli, R ;
Towbin, JA .
JOURNAL OF CLINICAL INVESTIGATION, 1996, 98 (06) :1355-1360
[2]  
BRINK PA, 1994, S AFR J SCI, V90, P236
[3]   Identification of a genetic locus for familial atrial fibrillation [J].
Brugada, R ;
Tapscott, T ;
Czernuszewicz, GZ ;
Marian, AJ ;
Iglesias, A ;
Mont, L ;
Brugada, J ;
Girona, J ;
Domingo, A ;
Bachinski, LL ;
Roberts, R .
NEW ENGLAND JOURNAL OF MEDICINE, 1997, 336 (13) :905-911
[4]  
CHANNER KS, 1988, BRIT HEART J, V59, P486
[5]   Genetically defined therapy of inherited long-QT syndrome - Correction of abnormal repolarization by potassium [J].
Compton, SJ ;
Lux, RL ;
Ramsey, MR ;
Strelich, KR ;
Sanguinetti, MC ;
Green, LS ;
Keating, MT ;
Mason, JW .
CIRCULATION, 1996, 94 (05) :1018-1022
[6]   AN ISOLATED CARDIAC CONDUCTION DISEASE MAPS TO CHROMOSOME 19Q [J].
DEMEEUS, A ;
STEPHAN, E ;
DEBRUS, S ;
JEAN, MK ;
LOISELET, J ;
WEISSENBACH, J ;
DEMAILLE, J ;
BOUVAGNET, P .
CIRCULATION RESEARCH, 1995, 77 (04) :735-740
[7]   LOCALIZATION OF A GENE RESPONSIBLE FOR FAMILIAL DILATED CARDIOMYOPATHY TO CHROMOSOME 1Q32 [J].
DURAND, JB ;
BACHINSKI, LL ;
BIELING, LC ;
CZERNUSZEWICZ, GZ ;
ABCHEE, AB ;
YU, QT ;
TAPSCOTT, T ;
HILL, R ;
IFEGWU, J ;
MARIAN, AJ ;
BRUGADA, R ;
DAIGER, S ;
GREGORITCH, JM ;
ANDERSON, JL ;
QUINONES, M ;
TOWBIN, JA ;
ROBERTS, R .
CIRCULATION, 1995, 92 (12) :3387-3389
[8]  
GILBERT EM, 1994, HEART, P1609
[9]   LINKAGE OF A CARDIAC-ARRHYTHMIA, THE LONG QT SYNDROME, AND THE HARVEY RAS-1 GENE [J].
KEATING, M ;
ATKINSON, D ;
DUNN, C ;
TIMOTHY, K ;
VINCENT, GM ;
LEPPERT, M .
SCIENCE, 1991, 252 (5006) :704-706
[10]   ARRHYTHMOGENIC RIGHT-VENTRICULAR DYSPLASIA CARDIOMYOPATHY - A REVIEW [J].
MARCUS, FI ;
FONTAINE, G .
PACE-PACING AND CLINICAL ELECTROPHYSIOLOGY, 1995, 18 (06) :1298-1314