Udenafil Enhances the Recovery of Erectile Function and Ameliorates the Pathophysiological Consequences of Cavernous Nerve Resection

被引：17

作者：

Lee, Chan-Ho ^{[1
]}

Shin, Jee-Hyun ^{[1
]}

Ahn, Gook-Jun ^{[1
]}

Kang, Kyung-Koo ^{[1
]}

Ahn, Byoung-Ok ^{[1
]}

Yoo, Moohi ^{[1
]}

机构：

[1] Dong A Pharmaceut Co, Res Lab, Yongin 446905, Gyeonggi, South Korea

来源：

JOURNAL OF SEXUAL MEDICINE | 2010年 / 7卷 / 07期

关键词：

Erectile Dysfunction; Cavernous Nerve Resection; Udenafil; Apoptosis; Fibrosis; TRANSFORMING GROWTH FACTOR-BETA(1); PHOSPHODIESTERASE TYPE-5 INHIBITOR; RADICAL PROSTATECTOMY; PENILE ERECTION; SMOOTH-MUSCLE; NITRIC-OXIDE; RAT MODEL; SILDENAFIL TREATMENT; PDE5; INHIBITOR; DYSFUNCTION;

D O I：

10.1111/j.1743-6109.2010.01858.x

中图分类号：

R5 [内科学]; R69 [泌尿科学（泌尿生殖系疾病）];

学科分类号：

1002 ; 100201 ;

摘要：

Introduction. Radical prostatectomy is the treatment of choice for prostate cancer patients. Despite the introduction of nerve-sparing surgical techniques, its success is not entirely guaranteed and the majority of patients report compromised erectile function following surgical procedures. Aim. This study was performed to investigate the effect of repeated dosing of udenafil, a novel phosphodiesterase type 5 inhibitor, on penile hypoxia and fibrosis induced by bilateral cavernous nerve resection (BCNR) in rats. Methods. Thirty male Sprague-Dawley rats (300-320 g) were used in this study. The animals were divided into three groups; group I consisted of sham-operated animals (N = 10), animals in group II underwent BCNR alone (N = 10), and animals in group III were orally treated with 1

引用

页码：2564 / 2571

页数：8

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