Stress-free T-cell development: glucocorticoids are not obligatory

被引：44
作者：
Godfrey, DI
Purton, JF
Boyd, RL
Cole, TJ
机构：
[1] Monash Univ, Sch Med, Dept Pathol & Immunol, Prahran, Vic 3181, Australia
[2] Baker Med Res Inst, Prahran, Vic 3181, Australia
来源：
IMMUNOLOGY TODAY | 2000年 / 21卷 / 12期
关键词：
D O I：
10.1016/S0167-5699(00)01741-2
中图分类号：
R392 [医学免疫学]; Q939.91 [免疫学];
学科分类号：
100102 ;
摘要：
A role for glucocorticoids in thymopoiesis has been suggested by studies using glucocorticoid receptor (GR) anti-sense transgenic mice, glucocorticoid synthesis inhibitors and GR antagonists. Unfortunately, no consensus has been reached on exactly how glucocorticoids influence T-cell development. The most recent approach using GR knockout (GR(-/-)) mice, indicates that GR signaling is, in fact, dispensable in this entire process.
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收藏
页码：606 / 611
页数：8
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