Individualized medication of digoxin based on the serum drug concentration and blood biochemical indexes

被引：6

作者：

Shen, Ji-zhong ^{[1
]}

Zhu, Huai-jun ^{[1
]}

Liu, Hang ^{[1
]}

Luo, Xue-mei ^{[1
]}

Jin, Lu ^{[1
]}

Li, Dan-yin ^{[1
]}

Zhang, Hai-xia ^{[1
]}

Ge, Wei-hong ^{[1
]}

机构：

[1] Nanjing Univ, Affiliated Nanjing Drum Tower Hosp, Med Sch, Dept Pharm, Nanjing 210008, Peoples R China

来源：

PERSONALIZED MEDICINE | 2020年 / 17卷 / 01期

基金：

中国国家自然科学基金;

关键词：

digoxin; drug toxicity; patient-specific modeling; pharmacovigilance; precision medicine; therapeutic drug monitoring; 2016 ESC GUIDELINES; HEART-FAILURE; COLLABORATION; ASSOCIATION; MANAGEMENT; POTASSIUM; DIAGNOSIS; TOXICITY;

D O I：

10.2217/pme-2019-0006

中图分类号：

R9 [药学];

学科分类号：

1007 ;

摘要：

Aim: The dose of digoxin is often difficult to be determined precisely. The aim of this study was to retrospectively investigate the effect of blood biochemical indexes on the serum concentration of digoxin. Materials & methods: We collected the data of hospitalized patients treated orally with digoxin in Nanjing Drum Tower Hospital (Nanjing, China) from 2016 to 2018. Descriptive statistics was used to analyze the patients' comprehensive condition. Results: A total of 425 patients were included in the study. Through analysis, nine factors were included in the regression model of the serum concentration of digoxin, and this regression model showed good predictive performance (r(2) = 0.83138; p < 0.001). Conclusion: The regression model for the prediction of serum concentration of digoxin has clinical significance, and can provide research basis for individualized medication of digoxin.

引用

页码：23 / 31

页数：9

共 25 条

[1] Effect of digoxin in patients with heart failure and mid-range (borderline) left ventricular ejection fraction [J].

Abdul-Rahim, Azmil H. ;

Shen, Li ;

Rush, Christopher J. ;

Jhund, Pardeep S. ;

Lees, Kennedy R. ;

McMurray, John J. V. .

EUROPEAN JOURNAL OF HEART FAILURE, 2018, 20 (07) :1139-1145

[2] Cardiovascular Drugs and Metformin Drug Dosage According to Renal Function in Non-Institutionalized Elderly Patients [J].

Becquemont, Laurent ;

Bauduceau, Bernard ;

Benattar-Zibi, Linda ;

Al-Salameh, Abdallah ;

Berrut, Gilles ;

Bertin, Philippe ;

Bucher, Sophie ;

Corruble, Emmanuelle ;

Danchin, Nicolas ;

Derumeaux, Genevieve ;

Doucet, Jean ;

Falissard, Bruno ;

Forette, Francoise ;

Hanon, Olivier ;

Pasquier, Florence ;

Pinget, Michel ;

Ourabah, Rissane ;

Piedvache, Celine .

BASIC & CLINICAL PHARMACOLOGY & TOXICOLOGY, 2016, 118 (06) :468-473

[3] A Population Pharmacokinetic Analysis of the Influence of Nutritional Status of Digoxin in Hospitalized Korean Patients [J].

Choi, Soo An ;

Yun, Hwi-yeol ;

Lee, Eun Sook ;

Shin, Wan Gyoon .

CLINICAL THERAPEUTICS, 2014, 36 (03) :389-400

[4] Evaluating Appropriateness of Digoxin, Carbamazepine, Valproic Acid, and Phenytoin Usage by Therapeutic Drug Monitoring [J].

Dalaklioglu, S. .

CLINICAL LABORATORY, 2013, 59 (3-4) :325-331

[5] K/DOQI clinical practice guidelines for chronic kidney disease: Evaluation, classification, and stratification - Foreword [J].

Eknoyan, G ;

Levin, NW .

AMERICAN JOURNAL OF KIDNEY DISEASES, 2002, 39 (02) :S14-S266

[6] Quality of requests for serum digoxin concentrations: experience from an Australian Regional Health Service [J].

Ellington, Chris ;

Grgurinovich, Nick ;

Miners, John O. ;

Mangoni, Arduino A. .

BRITISH JOURNAL OF CLINICAL PHARMACOLOGY, 2007, 63 (05) :623-627

[7] Digoxin: The Art and Science [J].

Ewy, Gordon A. .

AMERICAN JOURNAL OF MEDICINE, 2015, 128 (12) :1272-1274

[8] Therapeutic drug monitoring of digoxin-20 years of experience [J].

Grzesk, Grzegorz ;

Stolarek, Wioleta ;

Kasprzak, Michal ;

Krzyzanowski, Marek ;

Szadujkis-Szadurska, Katarzyna ;

Wicinski, Michal ;

Grzesk, Elzbieta .

PHARMACOLOGICAL REPORTS, 2018, 70 (01) :184-189

[9] 2009 Focused Update Incorporated Into the ACC/AHA 2005 Guidelines for the Diagnosis and Management of Heart Failure in Adults A Report of the American College of Cardiology Foundation/American Heart Association Task Force on Practice Guidelines Developed in Collaboration With the International Society for Heart and Lung Transplantation [J].

Hunt, Sharon Ann ;

Abraham, William T. ;

Chin, Marshall H. ;

Feldman, Arthur M. ;

Francis, Gary S. ;

Ganiats, Theodore G. ;

Jessup, Mariell ;

Konstam, Marvin A. ;

Mancini, Donna M. ;

Michl, Keith ;

Oates, John A. ;

Rahko, Peter S. ;

Silver, Marc A. ;

Stevenson, Lynne Warner ;

Yancy, Clyde W. ;

Casey, Donald E. ;

Smith, Sidney C., Jr. ;

Jacobs, Alice K. ;

Buller, Christopher E. ;

Creager, Mark A. ;

Ettinger, Steven M. ;

Krumholz, Harlan M. ;

Kushner, Frederick G. ;

Lytle, Bruce W. ;

Nishimura, Rick A. ;

Page, Richard L. ;

Tarkington, Lynn G. ;

Lewin, John C. ;

May, Charlene ;

Stewart, Mark D. ;

Keller, Sue ;

McDougall, Allison ;

Brown, Nancy ;

Whitman, Gayle R. .

JOURNAL OF THE AMERICAN COLLEGE OF CARDIOLOGY, 2009, 53 (15) :E1-E90

[10] 2016 ESC Guidelines for the management of atrial fibrillation developed in collaboration with EACTS [J].

Kirchhof, Paulus ;

Benussi, Stefano ;

Kotecha, Dipak ;

Ahlsson, Anders ;

Atar, Dan ;

Casadei, Barbara ;

Castella, Manuel ;

Diener, Hans-Christoph ;

Heidbuchel, Hein ;

Hendriks, Jeroen ;

Hindricks, Gerhard ;

Manolis, Antonis S. ;

Oldgren, Jonas ;

Popescu, Bogdan Alexandru ;

Schotten, Ulrich ;

Van Putte, Bart ;

Vardas, Panagiotis .

EUROPEAN HEART JOURNAL, 2016, 37 (38) :2893-+

← 1 2 3 →