Neuromyelitis optica

被引：0

作者：

Wildemann, B. ^{[1
]}

Jarius, S. ^{[1
]}

Paul, F. ^{[2
,3
]}

机构：

[1] Univ Klinikum Heidelberg, Sekt Mol Neuroimmunol, Neurol Klin, D-69120 Heidelberg, Germany

[2] Charite, Neurocure Clin Res Ctr, D-13353 Berlin, Germany

[3] Charite, Expt & Clin Res Ctr, D-13353 Berlin, Germany

来源：

NERVENARZT | 2013年 / 84卷 / 04期

关键词：

Neuromyelitis optica; Devic syndrome; Longitudinal extensive transverse myelitis; Recurrent optic neuritis; Aquaporin-4; antibodies; MYELIN-OLIGODENDROCYTE GLYCOPROTEIN; MULTIPLE-SCLEROSIS; MYASTHENIA-GRAVIS; SPECTRUM DISORDER; IGG PREDICTS; AQUAPORIN; T-CELLS; NMO-IGG; ANTIBODIES; DISEASE;

D O I：

10.1007/s00115-012-3602-x

中图分类号：

R74 [神经病学与精神病学];

学科分类号：

摘要：

The discovery of serum autoantibodies against the astrocytic water channel aquaporin-4 (AQP4) as a biomarker of neuromyelitis optica (NMO, Devic syndrome) has revolutionized our understanding of this rare immune-mediated clinical entity and has provided a rationale for the use of therapeutic strategies targeting the humoral effector arm of autoimmune responses. This article reviews the clinical features of NMO and highlights recent findings that have elucidated how antibodies and T cells with specificity for AQP4 may be involved in the pathophysiology of the disorder.

引用

页码：436 / +

页数：5

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