Endoplasmic reticulum-mitochondria contacts: function of the junction

被引：805

作者：

Rowland, Ashley A. ^{[1
]}

Voeltz, Gia K. ^{[1
]}

机构：

[1] Univ Colorado, Dept Mol Cellular & Dev Biol, Boulder, CO 80309 USA

来源：

NATURE REVIEWS MOLECULAR CELL BIOLOGY | 2012年 / 13卷 / 10期

基金：

美国国家卫生研究院;

关键词：

DYNAMIN-RELATED GTPASE; TO-TUBULE TRANSFORMATION; WD REPEAT PROTEIN; CLASS-V-MYOSIN; MOTOR-PROTEIN; ER; MEMBRANE; FISSION; INHERITANCE; DRP1;

D O I：

10.1038/nrm3440

中图分类号：

Q2 [细胞生物学];

学科分类号：

071009 ; 090102 ;

摘要：

The most well-characterized organelle contact sites are those between the endoplasmic reticulum (ER) and mitochondria. Increased understanding is being gained of how ER-mitochondria contact sites are organized and which factors converge at this interface, some of which may provide a tethering function. The role of the ER-mitochondria junction in coordinating the functions of these two organelles is also becoming clearer, and it has been shown to be involved in the regulation of lipid synthesis, Ca2+ signalling and the control of mitochondrial biogenesis and intracellular trafficking.

引用

页码：607 / 615

页数：9

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