A sequential two-component etherification/oxa-conjugate addition reaction: Asymmetric synthesis of (+)-leucascandrolide A macrolactone

被引：32

作者：

Evans, P. Andrew ^{[1
]}

Andrews, William J. ^{[2
]}

机构：

[1] Univ Liverpool, Dept Chem, Liverpool L69 7ZD, Merseyside, England

[2] Indiana Univ, Dept Chem, Bloomington, IN 47405 USA

来源：

ANGEWANDTE CHEMIE-INTERNATIONAL EDITION | 2008年 / 47卷 / 29期

关键词：

antifungal agents; asymmetric synthesis; cytotoxicity; natural products; total synthesis;

D O I：

10.1002/anie.200801357

中图分类号：

O6 [化学];

学科分类号：

0703 ;

摘要：

A smooth operator: The asymmetric synthesis of the macrolactone of (+)-leucascandrolide A (see structure) has been accomplished through a convergent route (longest linear sequence of 14 steps) in 20% overall yield. The assembly of the 1,5-bis(tetrahydropyran) core in a single operation provides the most concise synthetic approach developed to date. (Chemical Equation Presented) © 2008 Wiley-VCH Verlag GmbH & Co. KGaA.

引用

页码：5426 / 5429

页数：4

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