[11C]PIB PET Is Associated with the Brain Biopsy Amyloid-β Load in Subjects Examined for Normal Pressure Hydrocephalus

被引:9
作者
Rinne, Juha O. [1 ,2 ]
Suotunen, Timo [1 ]
Rummukainen, Jaana [3 ]
Herukka, Sanna-Kaisa [4 ,5 ]
Nerg, Ossi [4 ]
Koivisto, Anne M. [4 ,5 ]
Rauramaa, Tuomas [3 ,6 ]
Nagren, Kjell [7 ]
Hiltunen, Mikko [8 ]
Alafuzoff, Irina [9 ]
Rinne, Jaakko [10 ]
Jaaskelainen, Juha E. [11 ,12 ]
Soininen, Hilkka [5 ]
Leinonen, Ville [11 ,12 ,13 ,14 ]
机构
[1] Univ Turku, Turku PET Ctr, Kiinamyllynkatu 4-8, FIN-20520 Turku, Finland
[2] Turku Univ Hosp, Div Clin Neurosci, Turku, Finland
[3] Kuopio Univ Hosp, Dept Clin Pathol, Kuopio, Finland
[4] Kuopio Univ Hosp, Neurol NeuroCtr, Kuopio, Finland
[5] Univ Eastern Finland, Inst Clin Med, Neurol, Kuopio, Finland
[6] Univ Eastern Finland, Inst Clin Med, Pathol, Kuopio, Finland
[7] Odense Univ Hosp, PET & Cyclotron Unit, Dept Nucl Med, Odense, Denmark
[8] Univ Eastern Finland, Inst Biomed, Kuopio, Finland
[9] Uppsala Univ, Dept Immunol Genet & Pathol, Uppsala, Sweden
[10] Turku Univ Hosp, Dept Neurosurg, Clin Neurosci, Turku, Finland
[11] Univ Eastern Finland, Inst Clin Med, Neurosurg, Kuopio, Finland
[12] Kuopio Univ Hosp, Neurosurg NeuroCtr, Kuopio, Finland
[13] Univ Oulu, Unit Clin Neurosci, Neurosurg, Oulu, Finland
[14] Oulu Univ Hosp, Med Res Ctr, Oulu, Finland
基金
芬兰科学院;
关键词
Amyloid; brain biopsy; cerebrospinal fluid; normal pressure hydrocephalus; positron emission tomography; POSITRON-EMISSION-TOMOGRAPHY; CEREBROSPINAL-FLUID; ALZHEIMER-DISEASE; CSF BIOMARKERS; TAU PROTEINS; C-11-PIB PET; SHUNT; COMORBIDITY; CORRELATE;
D O I
10.3233/JAD-180645
中图分类号
Q189 [神经科学];
学科分类号
071006 ;
摘要
Background: Idiopathic normal pressure hydrocephalus (iNPH) is frequently associated with concomitant amyloid-beta (A beta) pathology. Objective: To compare the [C-11]PIB PET uptake in the patients with suspected iNPH to A beta and hyperphosphorylated-tau (HP tau) in the right frontal cortical biopsy, the cerebrospinal fluid (CSF) A beta, the response to a CSF shunt, and the final clinical diagnosis of Alzheimer's disease (AD). Methods: Patients (n = 21) from Kuopio NPH Registry (http://www.uef.fi/nph) with intraventricular pressure monitoring, immunostaining for A beta and HP tau in the right frontal cortical biopsies, and a Mini-Mental State Examination and a Clinical Dementia Rating underwent [C-1(1)]PIB PET. A beta, total tau, and P tau(181) were measured by ELISA from the ventricular (n= 15) and the lumbar (n = 9) CSF. Response to the shunt was seen in 13 out of the 15 shunted patients. AD was diagnosed in 8 patients during a median follow-up of 6 years (mean 7.3 +/- 2.4 years, range 3-1). Results: [C-11]PIB uptake in the right frontal cortex (rho = 0.60, p < 0.01) and the combined neocortical [C-11]PIB uptake score (rho = 0.61, p < 0.01) were associated with a higher A beta load in the right frontal cortical biopsy. Excluding one (1/15) outlier, [C-11]PIB uptake was also associated with the ventricular CSF A beta (rho = -0.58, p = 0.03). Conclusions: The findings show that [C-11]PIB PET can reliably detect simultaneous amyloid pathology among the iNPH patients. Further studies will show whether amyloid PET could predict a clinical response to the shunt operation. In addition, the presence of A beta pathology in the patients with iNPH might also warrant treatment with current AD drugs.
引用
收藏
页码:1343 / 1351
页数:9
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