The Complex Relationship between Liver Cancer and the Cell Cycle: A Story of Multiple Regulations

被引：76

作者：

Bisteau, Xavier ^{[1
]}

Caldez, Matias J. ^{[1
,2
]}

Kaldis, Philipp ^{[1
,2
]}

机构：

[1] ASTAR, IMCB, 61 Biopolis Dr,Proteos 3-09, Singapore 138673, Singapore

[2] NUS, Dept Biochem, Singapore 117597, Singapore

来源：

CANCERS | 2014年 / 6卷 / 01期

关键词：

cell cycle; cancer; liver; hepatocellular carcinoma; cyclin-dependent kinases; CKI; cyclins; VIRUS-X-PROTEIN; RETINOBLASTOMA TUMOR-SUPPRESSOR; HUMAN HEPATOCELLULAR-CARCINOMA; BETA-CATENIN MUTATIONS; D-DEPENDENT KINASES; NF-KAPPA-B; HEPATITIS-B; CORE PROTEIN; DOWN-REGULATION; C-MYC;

D O I：

10.3390/cancers6010079

中图分类号：

R73 [肿瘤学];

学科分类号：

100214 ;

摘要：

The liver acts as a hub for metabolic reactions to keep a homeostatic balance during development and growth. The process of liver cancer development, although poorly understood, is related to different etiologic factors like toxins, alcohol, or viral infection. At the molecular level, liver cancer is characterized by a disruption of cell cycle regulation through many molecular mechanisms. In this review, we focus on the mechanisms underlying the lack of regulation of the cell cycle during liver cancer, focusing mainly on hepatocellular carcinoma (HCC). We also provide a brief summary of novel therapies connected to cell cycle regulation.

引用

页码：79 / 111

页数：33

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