High pulse pressure is associated with an increased risk of diabetes in females but not in males: a retrospective cohort study

被引:6
作者
Jia, Sheng [1 ]
Wang, Xinyue [1 ]
Yao, Qing [1 ,2 ]
Gao, Jian [2 ]
机构
[1] Fudan Univ, Zhongshan Hosp, Dept Nutr, Xiamen Branch, Xiamen, Fujian, Peoples R China
[2] Fudan Univ, Zhongshan Hosp, Dept Nutr, Shanghai 200032, Peoples R China
关键词
Pulse pressure; Diabetes care; Sex differences; MEAN ARTERIAL-PRESSURE; BLOOD-PRESSURE; MELLITUS; PREDICTOR; STIFFNESS; POPULATION; GLUCOSE;
D O I
10.1186/s13293-022-00482-8
中图分类号
R5 [内科学];
学科分类号
1002 ; 100201 ;
摘要
ObjectiveAccumulating evidence suggests a close relationship between metabolic disturbance and increased arterial stiffness. However, whether there is an association between pulse pressure (PP) and diabetes and how this association might be impacted by sex is not clear. MethodsA total of 209,635 adult Chinese individuals > 20 years old across 32 sites and 11 cities in China (Shanghai, Beijing, Nanjing, Suzhou, Shenzhen, Changzhou, Chengdu, Guangzhou, Hefei, Wuhan, Nantong) were included in the study; participants were free of diabetes at baseline. In the present study, we analyzed the relationship between PP at baseline and incident diabetes using the Cox proportional hazard model. ResultsDuring a median follow-up of 2.99 years, a total of 3971 participants (2885 men and 1086 women) developed diabetes, and the incidence was 6.3 per 1000 person-years. With each 10 mmHg increase in PP, the multivariable adjusted hazard ratio (HR) (95% confidence interval) for incident diabetes was 1.117 (1.061, 1.176) in females and 0.981 (0.951, 1.012) in males. Using the lowest quartile of PP as the reference category, the hazard ratio (HR) (95% CI) of the highest quartile of PP for incident diabetes was 1.494 (1.225, 1.822) in females and 0.939 (0.843, 1.045) in males. Smooth plots revealed a significant difference between males and females in the HRs for new-onset diabetes according to PP. ConclusionHigher PP was related to future diabetes development in females but not in males and further research is needed to explore the mechanism.
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页数:7
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共 23 条
[1]   Association of body mass index and age with incident diabetes in Chinese adults: a population-based cohort study [J].
Chen, Ying ;
Zhang, Xiao-Ping ;
Yuan, Jie ;
Cai, Bo ;
Wang, Xiao-Li ;
Wu, Xiao-Li ;
Zhang, Yue-Hua ;
Zhang, Xiao-Yi ;
Yin, Tong ;
Zhu, Xiao-Hui ;
Gu, Yun-Juan ;
Cui, Shi-Wei ;
Lu, Zhi-Qiang ;
Li, Xiao-Ying .
BMJ OPEN, 2018, 8 (09)
[2]   Blood pressure and risk of developing type 2 diabetes mellitus: The Women's Health Study [J].
Conen, David ;
Ridker, Paul M. ;
Mora, Samia ;
Buring, Julie E. ;
Glynn, Robert J. .
EUROPEAN HEART JOURNAL, 2007, 28 (23) :2937-2943
[3]   Pulse pressure - A review of mechanisms and clinical relevance [J].
Dart, AM ;
Kingwell, BA .
JOURNAL OF THE AMERICAN COLLEGE OF CARDIOLOGY, 2001, 37 (04) :975-984
[4]  
Franklin SS, 1997, CIRCULATION, V96, P308
[5]   GLYCOSYLATED HEMOGLOBIN IN NORMAL SUBJECTS AND SUBJECTS WITH MATURITY-ONSET DIABETES - EVIDENCE FOR A SATURABLE SYSTEM IN MAN [J].
GRAF, RJ ;
HALTER, JB ;
PORTE, D .
DIABETES, 1978, 27 (08) :834-839
[6]   Arterial stiffness increases with deteriorating glucose tolerance status - The Hoorn Study [J].
Henry, RMA ;
Kostense, PJ ;
Spijkerman, AMW ;
Dekker, JM ;
Nijpels, G ;
Heine, RJ ;
Kamp, O ;
Westerhof, N ;
Bouter, LM ;
Stehouwer, CDA .
CIRCULATION, 2003, 107 (16) :2089-2095
[7]  
Janghorbani M, 2011, ENDOKRYNOL POL, V62, P324
[8]   Meta-Analysis of the Quantitative Relation Between Pulse Pressure and Mean Arterial Pressure and Cardiovascular Risk in Patients With Diabetes Mellitus [J].
Kodama, Satoru ;
Horikawa, Chika ;
Fujihara, Kazuya ;
Yoshizawa, Sakiko ;
Yachi, Yoko ;
Tanaka, Shiro ;
Ohara, Nobumasa ;
Matsunaga, Satoshi ;
Yamada, Takaho ;
Hanyu, Osamu ;
Sone, Hirohito .
AMERICAN JOURNAL OF CARDIOLOGY, 2014, 113 (06) :1058-1065
[9]   Impaired tissue perfusion - A pathology common to hypertension, obesity, and diabetes mellitus [J].
Levy, Bernard I. ;
Schiffrin, Ernesto L. ;
Mourad, Jean-Jacques ;
Agostini, Denis ;
Vicaut, Eric ;
Safar, Michel E. ;
Struijker-Boudier, Harry A. J. .
CIRCULATION, 2008, 118 (09) :968-976
[10]   Pulse pressure as an independent predictor of stroke: a systematic review and a meta-analysis [J].
Liu, Feng-Di ;
Shen, Xiao-Lei ;
Zhao, Rong ;
Tao, Xiao-Xiao ;
Wang, Shuo ;
Zhou, Jia-Jun ;
Zheng, Bo ;
Zhang, Qi-Ting ;
Yao, Qian ;
Zhao, Ying ;
Zhang, Xin ;
Wang, Xue-Mei ;
Liu, Hui-Qin ;
Shu, Liang ;
Liu, Jian-Ren .
CLINICAL RESEARCH IN CARDIOLOGY, 2016, 105 (08) :677-686