New Casbane Diterpenoids from a South China Sea Soft Coral, Sinularia sp.

被引：27

作者：

Yin, Jian ^{[1
]}

Zhao, Min ^{[1
]}

Ma, Minshan ^{[2
]}

Xu, Yuping ^{[1
]}

Xiang, Zheng ^{[1
]}

Cai, Yuepiao ^{[1
]}

Dong, Jianyong ^{[1
]}

Lei, Xinxiang ^{[2
]}

Huang, Kexin ^{[1
]}

Yan, Pengcheng ^{[1
]}

机构：

[1] Wenzhou Med Coll, Sch Pharm, Wenzhou 325035, Peoples R China

[2] Wenzhou Univ, Analyt & Testing Ctr, Wenzhou 325035, Peoples R China

来源：

MARINE DRUGS | 2013年 / 11卷 / 02期

关键词：

soft coral; Sinularia; casbane diterpenoids; cytotoxicity; NO inhibition; CYTOTOXIC DITERPENOIDS; AGROSTISTACHYS-HOOKERI; EUPHORBIA-PEKINENSIS; AGENTS;

D O I：

10.3390/md11020455

中图分类号：

R914 [药物化学];

学科分类号：

100701 ;

摘要：

Six new casbane diterpenoids, named as sinularcasbanes A-F (1-6), along with six known analogues 7-12, were isolated from a South China Sea soft coral, Sinularia sp. The structures of the new compounds were elucidated by extensive spectroscopic analysis and by comparison with data reported in the literature. All compounds were evaluated for their cytotoxicity against selected cancer cell lines and the inhibition of lipopolysaccharide (LPS)-induced nitric oxide (NO) production in mouse peritoneal macrophages.

引用

页码：455 / 465

页数：11

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