Cold microwave chemistry: synthesis using pre-cooled reagents

被引：17

作者：

Bose, AK ^{[1
]}

Ganguly, SN ^{[1
]}

Manhas, MS ^{[1
]}

He, W ^{[1
]}

Speck, J ^{[1
]}

机构：

[1] Stevens Inst Technol, Dept Chem & Biol Chem, George Barasch Bioorgan Res Lab, Hoboken, NJ 07030 USA

来源：

TETRAHEDRON LETTERS | 2006年 / 47卷 / 19期

关键词：

selective nitration reactions; nitration of phenols; microwave assisted nitration reactions; microwave irradiation of pre-cooled reagents;

D O I：

10.1016/j.tetlet.2006.03.059

中图分类号：

O62 [有机化学];

学科分类号：

070303 ; 081704 ;

摘要：

A novel experimental procedure for chemical reactions has been devised that involves mixing and then freezing the reagents (organic solvent-free) to a sub-zero temperature such as -30 degrees C. This frozen mixture is exposed to microwave irradiation for a brief period of time. The use of pre-cooled reagents may give a single product not obtained by traditional microwave irradiation at room temperature. Interestingly, such a product may provide information about mechanisms by identifying the first step of a multiple step reaction. (c) 2006 Elsevier Ltd. All rights reserved.

引用

页码：3213 / 3215

页数：3