Cold microwave chemistry: synthesis using pre-cooled reagents

被引:17
作者
Bose, AK [1 ]
Ganguly, SN [1 ]
Manhas, MS [1 ]
He, W [1 ]
Speck, J [1 ]
机构
[1] Stevens Inst Technol, Dept Chem & Biol Chem, George Barasch Bioorgan Res Lab, Hoboken, NJ 07030 USA
关键词
selective nitration reactions; nitration of phenols; microwave assisted nitration reactions; microwave irradiation of pre-cooled reagents;
D O I
10.1016/j.tetlet.2006.03.059
中图分类号
O62 [有机化学];
学科分类号
070303 ; 081704 ;
摘要
A novel experimental procedure for chemical reactions has been devised that involves mixing and then freezing the reagents (organic solvent-free) to a sub-zero temperature such as -30 degrees C. This frozen mixture is exposed to microwave irradiation for a brief period of time. The use of pre-cooled reagents may give a single product not obtained by traditional microwave irradiation at room temperature. Interestingly, such a product may provide information about mechanisms by identifying the first step of a multiple step reaction. (c) 2006 Elsevier Ltd. All rights reserved.
引用
收藏
页码:3213 / 3215
页数:3
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