A Markov model for the dynamics of the nucleosome

被引：2

作者：

van Opheusden, B. ^{[1
]}

Redig, F. ^{[2
]}

Schiessel, H. ^{[1
]}

机构：

[1] Leiden Univ, Inst Lorentz, NL-2300 RA Leiden, Netherlands

[2] Delft Inst Appl Math, NL-2628 CD Delft, Netherlands

来源：

JOURNAL OF PHYSICS A-MATHEMATICAL AND THEORETICAL | 2013年 / 46卷 / 09期

关键词：

EQUILIBRIUM ACCESSIBILITY; DNA; STABILITY; CHROMATIN; MECHANISM; MOBILITY; ACCESS;

D O I：

10.1088/1751-8113/46/9/095005

中图分类号：

O4 [物理学];

学科分类号：

0702 ;

摘要：

We study the dynamics of the nucleosome, the most abundant DNA protein complex in eukaryotic cells. The dynamics consist of two mechanisms, site exposure and sliding, which are crucial for making DNA accessible to DNA-binding proteins. The intertwining of both effects leads to a rich stochastic process that has not been studied before. Within the assumptions of our model, nucleosomes perform a symmetric random walk along the DNA strand. We investigate how the diffusion constant depends on the relative rates of site exposure and sliding.

引用

页数：15

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