Relative contribution of free-virus and synaptic transmission to the spread of HIV-1 through target cell populations

被引：49

作者：

Komarova, Natalia L. ^{[1
,2
]}

Anghelina, Daniela ^{[3
]}

Voznesensky, Igor ^{[3
]}

Trinite, Benjamin ^{[3
]}

Levy, David N. ^{[3
]}

Wodarz, Dominik ^{[1
,2
]}

机构：

[1] Univ Calif Irvine, Dept Math, Irvine, CA 92697 USA

[2] Univ Calif Irvine, Dept Ecol & Evolut, Irvine, CA 92697 USA

[3] NYU, Coll Dent, Dept Basic Sci, New York, NY 10010 USA

来源：

BIOLOGY LETTERS | 2013年 / 9卷 / 01期

关键词：

human immunodeficiency virus; mathematical model; virological synapse; REPLICATION;

D O I：

10.1098/rsbl.2012.1049

中图分类号：

Q [生物科学];

学科分类号：

07 ; 0710 ; 09 ;

摘要：

Human immunodeficiency virus can spread through target cells by transmission of cell-free virus or directly from cell-to-cell via formation of virological synapses. Although cell-to-cell transmission has been described as much more efficient than cell-free infection, the relative contribution of the two transmission pathways to virus growth during multiple rounds of replication remains poorly defined. Here, we fit a mathematical model to previously published and newly generated in vitro data, and determine that free-virus and synaptic transmission contribute approximately equally to the growth of the virus population.

引用

页数：6

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